高同型半胱氨酸血症和心血管疾病。

IF 0.4 4区医学 Q4 MEDICAL LABORATORY TECHNOLOGY

Annales de biologie clinique Pub Date : 2022-02-01 DOI:10.1684/abc.2021.1694

Régis Guieu, Jean Ruf, Giovanna Mottola

{"title":"高同型半胱氨酸血症和心血管疾病。","authors":"Régis Guieu, Jean Ruf, Giovanna Mottola","doi":"10.1684/abc.2021.1694","DOIUrl":null,"url":null,"abstract":"Homocysteine (Hcy) is a sulfhydryl-containing amino acid, which is not acquired through the diet, but rather synthesized as an intermediate metabolite in the methionine cycle. Hcy is present in plasma, with normal levels between 5 and 15 μmol/L, a slightly elevated level between 15 to 30 μmol/L, moderate from 30 to 100 μmol/L and a value > 100 μmol/L classified as severe hyperhomocysteinemia (HHcy). HHcy has been associated with inflammation and atherosclerosis and is considered an independent risk factor for cardiovascular diseases (CVD). Here, we review the main evidence showing the association and the possible involvement of HHcy in the most common CVD.","PeriodicalId":7892,"journal":{"name":"Annales de biologie clinique","volume":"80 1","pages":"7-14"},"PeriodicalIF":0.4000,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"9","resultStr":"{\"title\":\"Hyperhomocysteinemia and cardiovascular diseases.\",\"authors\":\"Régis Guieu, Jean Ruf, Giovanna Mottola\",\"doi\":\"10.1684/abc.2021.1694\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Homocysteine (Hcy) is a sulfhydryl-containing amino acid, which is not acquired through the diet, but rather synthesized as an intermediate metabolite in the methionine cycle. Hcy is present in plasma, with normal levels between 5 and 15 μmol/L, a slightly elevated level between 15 to 30 μmol/L, moderate from 30 to 100 μmol/L and a value > 100 μmol/L classified as severe hyperhomocysteinemia (HHcy). HHcy has been associated with inflammation and atherosclerosis and is considered an independent risk factor for cardiovascular diseases (CVD). Here, we review the main evidence showing the association and the possible involvement of HHcy in the most common CVD.\",\"PeriodicalId\":7892,\"journal\":{\"name\":\"Annales de biologie clinique\",\"volume\":\"80 1\",\"pages\":\"7-14\"},\"PeriodicalIF\":0.4000,\"publicationDate\":\"2022-02-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"9\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Annales de biologie clinique\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1684/abc.2021.1694\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"MEDICAL LABORATORY TECHNOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annales de biologie clinique","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1684/abc.2021.1694","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"MEDICAL LABORATORY TECHNOLOGY","Score":null,"Total":0}

引用次数: 9

摘要

同型半胱氨酸(Hcy)是一种含巯基的氨基酸，它不是通过饲料获得的，而是在蛋氨酸循环中作为中间代谢物合成的。Hcy存在于血浆中，正常水平为5 ~ 15 μmol/L，轻度升高为15 ~ 30 μmol/L，中度为30 ~ 100 μmol/L， > 100 μmol/L为重度高同型半胱氨酸血症(HHcy)。HHcy与炎症和动脉粥样硬化有关，被认为是心血管疾病(CVD)的独立危险因素。在这里，我们回顾了显示HHcy与最常见的心血管疾病相关和可能参与的主要证据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Hyperhomocysteinemia and cardiovascular diseases.

Homocysteine (Hcy) is a sulfhydryl-containing amino acid, which is not acquired through the diet, but rather synthesized as an intermediate metabolite in the methionine cycle. Hcy is present in plasma, with normal levels between 5 and 15 μmol/L, a slightly elevated level between 15 to 30 μmol/L, moderate from 30 to 100 μmol/L and a value > 100 μmol/L classified as severe hyperhomocysteinemia (HHcy). HHcy has been associated with inflammation and atherosclerosis and is considered an independent risk factor for cardiovascular diseases (CVD). Here, we review the main evidence showing the association and the possible involvement of HHcy in the most common CVD.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Annales de biologie clinique 医学-医学：研究与实验

CiteScore

0.80

自引率

20.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Multidisciplinary information with direct relevance to everyday practice Annales de Biologie Clinique, the official journal of the French Society of Clinical Biology (SFBC), supports biologists in areas including continuing education, laboratory accreditation and technique validation. With original articles, abstracts and accounts of everyday practice, the journal provides details of advances in knowledge, techniques and equipment, as well as a forum for discussion open to the entire community.