Ashraf Ahmed Nossair, Mona Kassem Kassem, Rasha Mounir Eltanamly, Yomna Amr Alahmadawy
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Corneal hysteresis (CH), corneal resistance factor (CRF), and IOP corneal compensated, IOP Goldmann corrected were assessed using ocular response analyzer (ORA), Corneal thickness was measured using optical coherence tomography, and IOP using Goldman applanation tonometer (IOP GAT).</p><p><strong>Results: </strong>There was a positive correlation between CH and CRF (<i>P</i> < 0.001 and <i>r</i> = 0.818) and (<i>P</i> < 0.001 and <i>r</i> = 0.714) in the active and inactive groups respectively, also between CRF and central corneal thickness (CCT) (<i>P</i> value 0.05 and <i>r</i> = 0.0435) in Inactive Group only. No correlation was found between CDAI score and ORA parameters. There was a negative correlation between CDAI and CCT in Active Group only (<i>P</i> < 0.001 and <i>r</i> = -0.823).</p><p><strong>Conclusion: </strong>Corneal biomechanical properties could be affected in rheumatoid patients in both active and remission phases, which may indicate that any corneal changes may be irreversible. These changes are of important significance regarding IOP measurement in rheumatoid patients. CCT may be a new parameter in the follow up of disease activity.</p>","PeriodicalId":18740,"journal":{"name":"Middle East African Journal of Ophthalmology","volume":null,"pages":null},"PeriodicalIF":0.5000,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8763098/pdf/","citationCount":"1","resultStr":"{\"title\":\"Corneal Hysteresis, Central Corneal Thickness, and Intraocular Pressure in Rheumatoid Arthritis, and Their Relation to Disease Activity.\",\"authors\":\"Ashraf Ahmed Nossair, Mona Kassem Kassem, Rasha Mounir Eltanamly, Yomna Amr Alahmadawy\",\"doi\":\"10.4103/meajo.meajo_434_20\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>To evaluate biomechanical properties, corneal thickness, and intraocular pressure (IOP) in patients with rheumatoid arthritis (RA) and correlate them with rheumatoid activity.</p><p><strong>Patients and methods: </strong>Forty RA eyes were enrolled in a cross-sectional study. 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引用次数: 1
摘要
目的:评估类风湿性关节炎(RA)患者的生物力学特性、角膜厚度和眼内压(IOP)及其与类风湿活动的相关性。患者和方法:40只RA眼被纳入横断面研究。临床疾病活动指数(CDAI)被风湿病学家用来评估类风湿活动。使用眼反应分析仪(ORA)评估角膜迟滞(CH)、角膜阻力因子(CRF)、角膜代偿性IOP、IOP Goldmann矫正性IOP,使用光学相干断层扫描测量角膜厚度,使用Goldman眼压计(IOP GAT)测量IOP。结果:运动组与不运动组CH与CRF呈正相关(P < 0.001, r = 0.818),不运动组CH与CRF呈正相关(P < 0.001, r = 0.714),不运动组CRF与角膜中央厚度(CCT)呈正相关(P值0.05,r = 0.0435)。CDAI评分与ORA参数无相关性。仅活跃组CDAI与CCT呈负相关(P < 0.001, r = -0.823)。结论:类风湿患者活动期和缓解期的角膜生物力学特性都可能受到影响,这可能表明任何角膜变化都可能是不可逆的。这些变化对类风湿患者IOP测量具有重要意义。CCT可能成为疾病活动性随访的新参数。
Corneal Hysteresis, Central Corneal Thickness, and Intraocular Pressure in Rheumatoid Arthritis, and Their Relation to Disease Activity.
Purpose: To evaluate biomechanical properties, corneal thickness, and intraocular pressure (IOP) in patients with rheumatoid arthritis (RA) and correlate them with rheumatoid activity.
Patients and methods: Forty RA eyes were enrolled in a cross-sectional study. Clinical Disease Activity Index (CDAI) was used to assess the rheumatoid activity by a rheumatologist. Corneal hysteresis (CH), corneal resistance factor (CRF), and IOP corneal compensated, IOP Goldmann corrected were assessed using ocular response analyzer (ORA), Corneal thickness was measured using optical coherence tomography, and IOP using Goldman applanation tonometer (IOP GAT).
Results: There was a positive correlation between CH and CRF (P < 0.001 and r = 0.818) and (P < 0.001 and r = 0.714) in the active and inactive groups respectively, also between CRF and central corneal thickness (CCT) (P value 0.05 and r = 0.0435) in Inactive Group only. No correlation was found between CDAI score and ORA parameters. There was a negative correlation between CDAI and CCT in Active Group only (P < 0.001 and r = -0.823).
Conclusion: Corneal biomechanical properties could be affected in rheumatoid patients in both active and remission phases, which may indicate that any corneal changes may be irreversible. These changes are of important significance regarding IOP measurement in rheumatoid patients. CCT may be a new parameter in the follow up of disease activity.
期刊介绍:
The Middle East African Journal of Ophthalmology (MEAJO), published four times per year in print and online, is an official journal of the Middle East African Council of Ophthalmology (MEACO). It is an international, peer-reviewed journal whose mission includes publication of original research of interest to ophthalmologists in the Middle East and Africa, and to provide readers with high quality educational review articles from world-renown experts. MEAJO, previously known as Middle East Journal of Ophthalmology (MEJO) was founded by Dr Akef El Maghraby in 1993.