8种ABCB1多态性对俄罗斯中重度抑郁症患者无治疗前瞻性队列抗抑郁反应的影响:一项自然设计的探索性精神药理学研究

IF 1.8 4区医学 Q3 CLINICAL NEUROLOGY

Human Psychopharmacology: Clinical and Experimental Pub Date : 2021-11-17 DOI:10.1002/hup.2826

Lisanne M. Geers, Taichi Ochi, Natalya M. Vyalova, Innokentiy S. Losenkov, Diana Z. Paderina, Ivan V. Pozhidaev, German G. Simutkin, Nikolay A. Bokhan, Bob Wilffert, Daniël J. Touw, Anton J.M. Loonen, Svetlana A. Ivanova

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引用次数: 3

摘要

许多抗抑郁药是p -糖蛋白的底物，p -糖蛋白是一种由ABCB1基因编码的血脑屏障外排转运蛋白。遗传变异可能影响抗抑郁药的转运率，从而影响其药理作用。本研究探讨了ABCB1基因的8个多态性对抗抑郁治疗反应的影响。方法选取托木斯克市精神卫生研究所精神科收治的152例患者。汉密尔顿抑郁评定量表(HAMD-17)得分在基线和第二周、第二周和第四周、基线和第四周之间的差异被用来估计抑郁症改善的时间。采用独立t检验和多元线性回归评估ABCB1基因多态性与HAMD-17评分降低之间的关系。结果与SSRIs相比，三环类抗抑郁药与HAMD-17评分的降低相关。SNP rs2235040 a等位基因对ΔHAMD-17(0→2W)评分有显著的正影响，对ΔHAMD-17(2→4W)评分有显著的负影响。rs4148739 g等位基因对ΔHAMD-17(0→2W)评分有显著负向影响，对ΔHAMD-17(2→4W)评分有显著正向影响。SNP rs2235015 t等位基因与ΔHAMD-17(2→4W)评分呈显著负相关。结论ABCB1基因变异影响抗抑郁药物反应的速度，但不影响其程度。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Influence of eight ABCB1 polymorphisms on antidepressant response in a prospective cohort of treatment-free Russian patients with moderate or severe depression: An explorative psychopharmacological study with naturalistic design

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Background

Many antidepressants are substrates of P-glycoprotein, an efflux transporter in the blood-brain-barrier encoded by the ABCB1 gene. Genetic variations might influence the transport rate of antidepressants and hence their pharmacological effects. This study investigates the influence of eight polymorphisms in the ABCB1 gene on antidepressant treatment response.

Method

152 patients were included from psychiatric departments of the Mental Health Research Institute in Tomsk. The difference in Hamilton-Depression-Rating-Scale (HAMD-17)-scores between baseline and week two, week two and four, and baseline and week four was used to estimate timing of improvement of depression. Associations between the ABCB1 gene-polymorphisms and reduction in HAMD-17 score were assessed using independent t-test and multiple linear regression.

Results

Tricyclic antidepressants were associated with a higher reduction of HAMD-17 score when compared to SSRIs. The SNP rs2235040 A-allele had a significant positive influence on the ΔHAMD-17_(0→2W) score but a significant negative influence on the ΔHAMD-17_(2→4W) score. The rs4148739 G-allele had a significant negative influence on the ΔHAMD-17_(0→2W) score but a significant positive influence on the ΔHAMD-17_(2→4W) score. The SNP rs2235015 T-allele is significant negatively related to the ΔHAMD-17_(2→4W) score.

Conclusion

ABCB1 Genetic variations appear to affect speed but not magnitude of antidepressant drug response.

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来源期刊

Human Psychopharmacology: Clinical and Experimental 医学-精神病学

CiteScore

4.10

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Human Psychopharmacology: Clinical and Experimental provides a forum for the evaluation of clinical and experimental research on both new and established psychotropic medicines. Experimental studies of other centrally active drugs, including herbal products, in clinical, social and psychological contexts, as well as clinical/scientific papers on drugs of abuse and drug dependency will also be considered. While the primary purpose of the Journal is to publish the results of clinical research, the results of animal studies relevant to human psychopharmacology are welcome. The following topics are of special interest to the editors and readers of the Journal: -All aspects of clinical psychopharmacology- Efficacy and safety studies of novel and standard psychotropic drugs- Studies of the adverse effects of psychotropic drugs- Effects of psychotropic drugs on normal physiological processes- Geriatric and paediatric psychopharmacology- Ethical and psychosocial aspects of drug use and misuse- Psychopharmacological aspects of sleep and chronobiology- Neuroimaging and psychoactive drugs- Phytopharmacology and psychoactive substances- Drug treatment of neurological disorders- Mechanisms of action of psychotropic drugs- Ethnopsychopharmacology- Pharmacogenetic aspects of mental illness and drug response- Psychometrics: psychopharmacological methods and experimental design