脂肪组织巨噬细胞在衰老相关的脂肪组织功能中的作用。

IF 2.6 4区医学 Q2 PHYSIOLOGY

Journal of Physiological Sciences Pub Date : 2021-12-04 DOI:10.1186/s12576-021-00820-2

Bangchao Lu, Liang Huang, Juan Cao, Lingling Li, Wenhui Wu, Xiaolin Chen, Congzhu Ding

{"title":"脂肪组织巨噬细胞在衰老相关的脂肪组织功能中的作用。","authors":"Bangchao Lu, Liang Huang, Juan Cao, Lingling Li, Wenhui Wu, Xiaolin Chen, Congzhu Ding","doi":"10.1186/s12576-021-00820-2","DOIUrl":null,"url":null,"abstract":"\"Inflammaging\" refers to the chronic, low-grade inflammation that characterizes aging. Aging, like obesity, is associated with visceral adiposity and insulin resistance. Adipose tissue macrophages (ATMs) have played a major role in obesity-associated inflammation and insulin resistance. Macrophages are elevated in adipose tissue in aging. However, the changes and also possibly functions of ATMs in aging and aging-related diseases are unclear. In this review, we will summarize recent advances in research on the role of adipose tissue macrophages with aging-associated insulin resistance and discuss their potential therapeutic targets for preventing and treating aging and aging-related diseases.","PeriodicalId":16832,"journal":{"name":"Journal of Physiological Sciences","volume":"71 1","pages":"38"},"PeriodicalIF":2.6000,"publicationDate":"2021-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10717320/pdf/","citationCount":"0","resultStr":"{\"title\":\"Adipose tissue macrophages in aging-associated adipose tissue function.\",\"authors\":\"Bangchao Lu, Liang Huang, Juan Cao, Lingling Li, Wenhui Wu, Xiaolin Chen, Congzhu Ding\",\"doi\":\"10.1186/s12576-021-00820-2\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"\\\"Inflammaging\\\" refers to the chronic, low-grade inflammation that characterizes aging. Aging, like obesity, is associated with visceral adiposity and insulin resistance. Adipose tissue macrophages (ATMs) have played a major role in obesity-associated inflammation and insulin resistance. Macrophages are elevated in adipose tissue in aging. However, the changes and also possibly functions of ATMs in aging and aging-related diseases are unclear. In this review, we will summarize recent advances in research on the role of adipose tissue macrophages with aging-associated insulin resistance and discuss their potential therapeutic targets for preventing and treating aging and aging-related diseases.\",\"PeriodicalId\":16832,\"journal\":{\"name\":\"Journal of Physiological Sciences\",\"volume\":\"71 1\",\"pages\":\"38\"},\"PeriodicalIF\":2.6000,\"publicationDate\":\"2021-12-04\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10717320/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Physiological Sciences\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1186/s12576-021-00820-2\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"PHYSIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Physiological Sciences","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s12576-021-00820-2","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PHYSIOLOGY","Score":null,"Total":0}

引用次数: 0

摘要

"炎症 "是指慢性、低度炎症，它是衰老的特征。衰老与肥胖一样，与内脏脂肪和胰岛素抵抗有关。脂肪组织巨噬细胞（ATMs）在肥胖相关的炎症和胰岛素抵抗中扮演着重要角色。在衰老过程中，脂肪组织中的巨噬细胞会升高。然而，ATMs 在衰老和衰老相关疾病中的变化和可能的功能尚不清楚。在本综述中，我们将总结有关脂肪组织巨噬细胞在衰老相关的胰岛素抵抗中的作用的最新研究进展，并讨论其在预防和治疗衰老及衰老相关疾病方面的潜在治疗靶点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Adipose tissue macrophages in aging-associated adipose tissue function.

"Inflammaging" refers to the chronic, low-grade inflammation that characterizes aging. Aging, like obesity, is associated with visceral adiposity and insulin resistance. Adipose tissue macrophages (ATMs) have played a major role in obesity-associated inflammation and insulin resistance. Macrophages are elevated in adipose tissue in aging. However, the changes and also possibly functions of ATMs in aging and aging-related diseases are unclear. In this review, we will summarize recent advances in research on the role of adipose tissue macrophages with aging-associated insulin resistance and discuss their potential therapeutic targets for preventing and treating aging and aging-related diseases.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Journal of Physiological Sciences 医学-生理学

CiteScore

4.40

自引率

4.30%

发文量

审稿时长

6-12 weeks

期刊介绍： The Journal of Physiological Sciences publishes peer-reviewed original papers, reviews, short communications, technical notes, and letters to the editor, based on the principles and theories of modern physiology and addressed to the international scientific community. All fields of physiology are covered, encompassing molecular, cellular and systems physiology. The emphasis is on human and vertebrate physiology, but comparative papers are also considered. The process of obtaining results must be ethically sound. Fields covered: Adaptation and environment Autonomic nervous function Biophysics Cell sensors and signaling Central nervous system and brain sciences Endocrinology and metabolism Excitable membranes and neural cell physiology Exercise physiology Gastrointestinal and kidney physiology Heart and circulatory physiology Molecular and cellular physiology Muscle physiology Physiome/systems biology Respiration physiology Senses.