治疗药物监测指导氟康唑治疗胆管炎脓毒症1例。

IF 1.7 4区医学 Q3 PHARMACOLOGY & PHARMACY

Personalized medicine Pub Date : 2022-01-01 Epub Date: 2021-11-08 DOI:10.2217/pme-2021-0010

Jana Duricova, Pavla Jadrnickova, Hana Brozmanova, Ivana Kacirova

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引用次数: 1

摘要

念珠菌和其他真菌种类在医院感染中起着越来越重要的作用，包括胆管炎和胆管败血症。早期诊断和及时治疗对患者的成功预后至关重要。氟康唑是氟康唑敏感念珠菌感染的首选抗真菌药物。关于氟康唑胆排泄的信息知之甚少。组织穿透减少可能是治疗失败的可能原因之一。由于良好的药代动力学，这种抗真菌药物的治疗监测尚未被常规推荐。在本病例中，我们报告了治疗药物监测引导氟康唑治疗由氟康唑敏感念珠菌引起的胆管炎和胆管败血症患者的成功。

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Therapeutic drug monitoring guided fluconazole therapy in a patient with cholangitis sepsis.

Candida and other fungal species play an increasing role in nosocomial infections, including cholangitis and cholangiosepsis. Early diagnosis and prompt treatment are essential in successful patient outcomes. Fluconazole is an antifungal of choice in fluconazole-sensitive Candida infections. Little information is known about the fluconazole biliary excretion. Decreased tissue penetration may be one of the possible causes of treatment failure. Due to favorable pharmacokinetics, therapeutic drug monitoring of this antifungal has not been recommended routinely. In the presented case we report the successful therapeutic drug monitoring-guided fluconazole treatment in a patient with cholangitis and cholangiosepsis caused by fluconazole-sensitive Candida spp.

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来源期刊

Personalized medicine 医学-药学

CiteScore

3.30

自引率

4.30%

发文量

审稿时长

6-12 weeks

期刊介绍： Personalized Medicine (ISSN 1741-0541) translates recent genomic, genetic and proteomic advances into the clinical context. The journal provides an integrated forum for all players involved - academic and clinical researchers, pharmaceutical companies, regulatory authorities, healthcare management organizations, patient organizations and others in the healthcare community. Personalized Medicine assists these parties to shape thefuture of medicine by providing a platform for expert commentary and analysis. The journal addresses scientific, commercial and policy issues in the field of precision medicine and includes news and views, current awareness regarding new biomarkers, concise commentary and analysis, reports from the conference circuit and full review articles.