从小鼠遗传学到靶向Rag GTPase途径。

IF 2.6 Q3 ONCOLOGY

Molecular and Cellular Oncology Pub Date : 2021-09-24 eCollection Date: 2021-01-01 DOI:10.1080/23723556.2021.1979370

Ana Ortega-Molina, Alejo Efeyan

引用次数: 0

摘要

Rag GTPases的鉴定开启了对雷帕霉素(rapamycin, mTOR)的营养信号传导机制的分子谜题的解读，并激发了人们对这一途径的兴趣，以对抗人类疾病。最近的小鼠遗传学研究提供了病理生理学的见解，并指出了Rag GTPase途径抑制剂的潜在适应症。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

From mouse genetics to targeting the Rag GTPase pathway.

查看原文本刊更多论文

From mouse genetics to targeting the Rag GTPase pathway.

The identification of the Rag GTPases initiated the deciphering of the molecular puzzle of nutrient signaling to the mechanistic target of rapamycin (mTOR), and spurred interest in targeting this pathway to combat human disease. Recent mouse genetic studies have provided pathophysiological insight and pointed to potential indications for inhibitors of the Rag GTPase pathway.

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来源期刊

Molecular and Cellular Oncology Biochemistry, Genetics and Molecular Biology-Cancer Research

CiteScore

3.20

自引率

0.00%

发文量

期刊介绍： For a long time, solid neoplasms have been viewed as relatively homogeneous entities composed for the most part of malignant cells. It is now clear that tumors are highly heterogeneous structures that evolve in the context of intimate interactions between cancer cells and endothelial, stromal as well as immune cells. During the past few years, experimental and clinical oncologists have witnessed several conceptual transitions of this type. Molecular and Cellular Oncology (MCO) emerges within this conceptual framework as a high-profile forum for the publication of fundamental, translational and clinical research on cancer. The scope of MCO is broad. Submissions dealing with all aspects of oncogenesis, tumor progression and response to therapy will be welcome, irrespective of whether they focus on solid or hematological neoplasms. MCO has gathered leading scientists with expertise in multiple areas of cancer research and other fields of investigation to constitute a large, interdisciplinary, Editorial Board that will ensure the quality of articles accepted for publication. MCO will publish Original Research Articles, Brief Reports, Reviews, Short Reviews, Commentaries, Author Views (auto-commentaries) and Meeting Reports dealing with all aspects of cancer research.