乳头瘤病毒在乳腺癌新鲜组织中流行的系统评价和荟萃分析。

Breast disease Pub Date : 2022-01-01 DOI:10.3233/BD-201032

Geilson Gomes de Oliveira, Ana Katherine Gonçalves, José Eleutério, Luiz Gonzaga Porto Pinheiro

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引用次数: 1

摘要

背景:虽然被广泛研究，但由于研究结果的多样性，HPV在乳腺癌发生中的作用仍然难以捉摸，这可能是由于方法的广泛异质性，其中一些方法不充分。目的:通过对使用公认的病毒检测和组织保存技术的研究进行荟萃分析，验证HPV与乳腺癌之间的关联。方法:系统回顾和荟萃分析仅限于用PCR检测乳腺癌新鲜和冷冻组织中HPV的研究，以获得更大的同质性。PubMed、Scopus、Science Direct、Cochrane Library和SciELO被检索到2019年12月14日。搜索词包括“乳腺癌”和“HPV”，没有语言限制。荟萃分析纳入了11项研究。计算合并相对风险和95%置信区间(95% CI)，并使用i²(I2)评估异质性。结果:所选研究的异质性非常低(2%)。在乳腺癌中检测到HPV的联合相对危险度(95% CI = 1.60-2.89)是无癌乳腺癌对照组的2.15倍，p值有统计学意义(p)。结论:我们的数据支持DNA-HPV与乳腺癌的关联。需要进一步的研究来找出这种关联最常见的乳腺癌亚型。

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Systematic review and meta-analysis of the papillomavirus prevalence in breast cancer fresh tissues.

Background: Although widely studied, the role of HPV in the genesis of breast carcinomas remains elusive due to the diversity of results across studies, possibly caused by the wide methodological heterogeneity, some of them with inadequate methods.

Objective: To verify the association between HPV and breast cancer through the meta-analysis of studies that used the best-recognized techniques for viral detection and tissue conservation.

Methods: A systematic review and meta-analysis restricted to studies that detected HPV by PCR in fresh and frozen tissue from breast cancer were conducted to obtain greater homogeneity. PubMed, Scopus, Science Direct, Cochrane Library, and SciELO were searched until December 14, 2019. Search terms included "breast cancer" and "HPV" without language restrictions. Eleven studies were included in the meta-analysis. The pooled relative risks and 95% confidence interval (95% CI) were calculated, and heterogeneity was assessed using the I-squared (I2).

Results: The selected studies had very low heterogeneity (2%). There is a 2.15 times higher combined relative risk (95% CI = 1.60-2.89) of detecting HPV in breast cancer than in cancer-free breast controls with a statistically significant p-value (p < 0.0001).

Conclusion: Our data support the association of DNA-HPV with breast carcinomas. Further studies are needed to find out which breast cancer subtypes this association is most frequent.

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来源期刊

Breast disease Medicine-Oncology

CiteScore

1.80

自引率

0.00%

发文量

期刊介绍： The recent expansion of work in the field of breast cancer inevitably will hasten discoveries that will have impact on patient outcome. The breadth of this research that spans basic science, clinical medicine, epidemiology, and public policy poses difficulties for investigators. Not only is it necessary to be facile in comprehending ideas from many disciplines, but also important to understand the public implications of these discoveries. Breast Disease publishes review issues devoted to an in-depth analysis of the scientific and public implications of recent research on a specific problem in breast cancer. Thus, the reviews will not only discuss recent discoveries but will also reflect on their impact in breast cancer research or clinical management.