对纤维化患者真皮中预弹性纤维合成的生理刺激。

IF 0.8 Q3 MEDICINE, GENERAL & INTERNAL
Case Reports in Medicine Pub Date : 2021-12-30 eCollection Date: 2021-01-01 DOI:10.1155/2021/2666867
Jose Maria Pereira de Godoy, Lívia Maria Pereira de Godoy, Maria de Fatima Guerreiro Godoy, Dalisio de Santi Neto
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引用次数: 9

摘要

目的:本研究的目的是报道生理刺激的合成前弹性纤维在真皮纤维化患者。设计:进行了一项临床研究,分析II期原发性淋巴水肿治疗后前弹性纤维的组织学变化,以临床逆转淋巴水肿和纤维化。设置。医学院圣若泽·里奥普雷图大学医院,2020年。参与者是一名67岁男性患者,12年前诊断为迟发性原发性淋巴水肿。干预是淋巴刺激使用戈多伊法适用于治疗纤维化。主要观察结果和措施为治疗前后活检。采用多点形态测量法对随机选取的10个组织学场进行评价。这种方法的值是相对的,用百分比表示。采用t检验进行统计分析,考虑95%显著性水平。结果:干预前与干预后载玻片的预弹性纤维百分比有明显差异,显微评价和定量证实了这一点(分别为4.95±0.64%和14.70±1.06%)。结论:采用特定方法对淋巴系统进行生理刺激,可使临床纤维化减少,皮肤弹性恢复,刺激前弹性纤维合成。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Physiological Stimulation of the Synthesis of Preelastic Fibers in the Dermis of a Patient with Fibrosis.

Physiological Stimulation of the Synthesis of Preelastic Fibers in the Dermis of a Patient with Fibrosis.

Objective: The aim of the present study was to report the physiological stimulation of the synthesis of preelastic fibers in the dermis of a patient with fibrosis.

Design: A clinical study was conducted involving the analysis of histological changes in preelastic fibers following treatment for stage II primary lymphedema for the clinical reversal of lymphedema and fibrosis. Setting. University Hospital of the São Jose do Rio Preto of School of Medicine in 2020. Participant was a 67-year-old male patient with late-onset primary lymphedema diagnosed 12 years earlier. Intervention is the lymphatic stimulation using the Godoy method adapted to the treatment of fibrosis. Main outcomes and measures are biopsies before and after treatment. Ten randomly selected histological fields were evaluated using the multipoint morphometric method. The values with this method are relative and expressed as percentages. Statistical analysis was performed with the t-test, considering a 95% significance level.

Results: A visible, significant difference in the percentage of preelastic fibers was found between the preintervention and postintervention slides, which were confirmed by the microscopic evaluation and quantification (4.95 ± 0.64% and 14.70 ± 1.06%, respectively).

Conclusion: The physiological stimulation of the lymphatic system using a specific method resulted in the clinical reduction of fibrosis, the return of the elasticity of the skin, and the stimulation of the synthesis of preelastic fibers.

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来源期刊
Case Reports in Medicine
Case Reports in Medicine MEDICINE, GENERAL & INTERNAL-
CiteScore
1.70
自引率
0.00%
发文量
53
审稿时长
13 weeks
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