网织红细胞血红蛋白当量:评估甲状腺功能减退患者缺铁的诊断性能。

IF 2.2 Q3 HEMATOLOGY

Anemia Pub Date : 2021-11-12 eCollection Date: 2021-01-01 DOI:10.1155/2021/9071057

Wardah Aslam, Maryam Habib, Saeeda Aziz, Madiha Habib

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引用次数: 4

摘要

简介:缺铁影响约30%的世界人口，并经常遇到甲状腺功能低下的患者。早期发现并及时治疗甲状腺功能减退患者缺铁可获得良好的预后。本研究的目的是证明网织红细胞血红蛋白当量(Ret-He)作为诊断甲状腺功能减退患者缺铁的可靠和有效的工具。材料与方法:纳入154例甲状腺功能减退患者。他们被分成4组。第一组66例甲状腺功能减退患者，无缺铁。他们被作为对照。2组66例甲状腺功能减退伴缺铁性贫血(IDA)。第三组包括12例缺铁但无贫血(ID)的甲状腺功能减退患者。第4组包括10例甲状腺功能减退伴慢性障碍性贫血(ACDC)的缺铁患者。Ret-He通过分析xn350系统的血液样本来测量。甲状腺轮廓、血清铁蛋白和生化数据由自动分析仪测量。采用SPSS 23进行统计学分析。结果:与对照组1(不缺铁的甲状腺功能减退患者)相比，组2(伴有IDA的甲状腺功能减退患者)、组3(伴有ID的甲状腺功能减退患者)和组4(伴有ACDC的甲状腺功能减退患者)的Ret-He显著降低(p < 0.001)。经ROC分析，甲状腺功能减退伴IDA患者的Ret-He曲线下面积(AUC)为0.96，截止时间为28.5 pg，敏感性93%，特异性90%。甲状腺功能减退伴ACDC组Ret-He的AUC为0.99，截止值为30.8 pg，敏感性90%，特异性90%。甲状腺功能减退合并ID患者Ret-He的AUC为0.97，截止值为31.7 pg，敏感性为91%，特异性为70%。结论:Ret-He是诊断甲状腺功能减退患者缺铁的一种可靠、快速、经济的工具。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Reticulocyte Hemoglobin Equivalent: Diagnostic Performance in Assessment of Iron Deficiency in Patients with Hypothyroidism.

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Reticulocyte Hemoglobin Equivalent: Diagnostic Performance in Assessment of Iron Deficiency in Patients with Hypothyroidism.

Introduction Iron deficiency affects approximately 30% of the world population and is frequently encountered in hypothyroid patients. Early recognition and prompt treatment of iron deficiency in hypothyroid patients lead to a favorable outcome. The aim of this study is to prove the usefulness of reticulocyte hemoglobin equivalent (Ret-He) as a reliable and effective tool in diagnosis of iron deficiency in hypothyroid patients. Materials and Methods 154 patients with hypothyroidism were included in the study. They were divided into 4 groups. Group 1 included 66 hypothyroid patients without iron deficiency. They were taken as controls. Group 2 included 66 hypothyroid patients with iron deficiency anemia (IDA). Group 3 included 12 hypothyroid patients with iron deficiency but without anemia (ID). Group 4 included 10 hypothyroid patients which had concomitant iron deficiency with anemia of chronic disorder (ACDC). Ret-He was measured by analyzing blood samples on System XN 350. Thyroid profile, serum ferritin, and biochemical data were measured by an automated analyzer. Statistical analysis was performed by using SPSS 23. Results Ret-He was significantly lower with (p < 0.001) in group 2 (hypothyroid patients with IDA), group 3 (hypothyroid patients with ID), and in group 4 (hypothyroid patients with ACDC) as compared to controls in group 1 (hypothyroid patients without iron deficiency). After ROC analysis area under the curve (AUC) of Ret-He for hypothyroid patients with IDA was 0.96 at cutoff 28.5 pg with sensitivity of 93% and specificity of 90%. AUC of Ret-He in the hypothyroid group with ACDC was 0.99 at cutoff 30.8 pg with sensitivity of 90% and specificity of 90%. AUC of Ret-He in hypothyroid patients with ID was 0.97 at cutoff 31.7 pg with sensitivity of 91% and specificity of 70%. Conclusion Ret-He is a reliable, rapid, and cost-effective tool for diagnosing iron deficiency in hypothyroid patients.

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来源期刊

Anemia HEMATOLOGY-

CiteScore

4.80

自引率

3.40%

发文量

审稿时长

18 weeks

期刊介绍： Anemia is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies on all types of anemia. Articles focusing on patient care, health systems, epidemiology, and animal models will be considered, among other relevant topics. Affecting roughly one third of the world’s population, anemia is a major public health concern. The journal aims to facilitate the exchange of research addressing global health and mortality relating to anemia and associated diseases.