SARS-CoV-2病毒及其组装的结构视图

IF 5.7 2区医学 Q1 VIROLOGY

Current opinion in virology Pub Date : 2022-02-01 DOI:10.1016/j.coviro.2021.11.011

Nathan J Hardenbrook , Peijun Zhang

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引用次数: 34

摘要

2019年爆发的SARS-CoV-2大流行使世界陷入瘫痪，造成数亿病例和数百万人死亡。在此期间，我们看到科学家们为应对这一致命疾病提供了前所未有的支持和合作。结构生物学领域的进步，特别是低温电子显微镜和低温电子断层扫描，使得对SARS-CoV-2进行前所未有的结构分析成为可能。在此，我们回顾了SARS-CoV-2病毒及其成分及其细胞组装过程的结构工作，重点介绍了一些重要的结构发现，这些发现对新发病毒感染的保护和治疗产生了重大影响。

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A structural view of the SARS-CoV-2 virus and its assembly

The SARS-CoV-2 pandemic that struck in 2019 has left the world crippled with hundreds of millions of cases and millions of people dead. During this time, we have seen unprecedented support and collaboration amongst scientists to respond to this deadly disease. Advances in the field of structural biology, in particular cryoEM and cryo-electron tomography, have allowed unprecedented structural analysis of SARS-CoV-2. Here, we review the structural work on the SARS-CoV-2 virus and viral components, as well as its cellular assembly process, highlighting some important structural findings that have made significant impact on the protection from and treatment of emerging viral infections.

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来源期刊

Current opinion in virology VIROLOGY-

CiteScore

11.80

自引率

5.10%

发文量

审稿时长

83 days

期刊介绍： Current Opinion in Virology (COVIRO) is a systematic review journal that aims to provide specialists with a unique and educational platform to keep up to date with the expanding volume of information published in the field of virology. It publishes 6 issues per year covering the following 11 sections, each of which is reviewed once a year: Emerging viruses: interspecies transmission; Viral immunology; Viral pathogenesis; Preventive and therapeutic vaccines; Antiviral strategies; Virus structure and expression; Animal models for viral diseases; Engineering for viral resistance; Viruses and cancer; Virus vector interactions. There is also a section that changes every year to reflect hot topics in the field.