MRI表观扩散系数(ADC):前列腺癌放射治疗后的生物标志物。

IF 1 Q4 UROLOGY & NEPHROLOGY

Turkish journal of urology Pub Date : 2021-11-01 DOI:10.5152/tud.2021.21274

Michele Scialpi, Eugenio Martorana, Pietro Scialpi, Alfredo D'Andrea, Francesco Maria Mancioli, Marcello Mignogna, Aldo Di Blasi, Fabio Trippa

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引用次数: 1

摘要

前列腺特异性抗原(PSA)仍然是评估包括放射治疗(RT)在内的治疗后反应的最常用测试。从常规弥散加权成像(DWI)得到的表观扩散系数(ADC)作为非对比或双参数MRI (bpMRI) (t2加权和DWI)的一部分，提供与多参数MRI相当的诊断准确性和癌症检出率。早在放疗后3个月，通过ADC图上肿瘤信号强度的增加，就可以定性地证明放疗引起的细胞改变。ADC与PSA相关，代表了在放疗期间和放疗后不久评估PCa治疗效果的潜在生物标志物成像。

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MRI apparent diffusion coefficient (ADC): A biomarker for prostate cancer after radiation therapy.

Prostate specific antigen (PSA) remains the most used test to assess the response after therapies including the radiation therapy (RT). Apparent diffusion coefficient (ADC) derived from the conventional diffusionweighted imaging (DWI), as a part of noncontrast or biparametric MRI (bpMRI) (T2-weighted and DWI), offers diagnostic accuracy and cancer detection rate equivalent to that of multiparametric MRI. Cellular changes induced by RT can be quali-qualitatively demonstrated as early as 3months after RT as an increase in the signal intensity of the tumor on the ADC map. ADC, in association with PSA, represents a potential biomarker imaging for evaluating treatment efficacy in PCa both during and shortly after RT.

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来源期刊

Turkish journal of urology Medicine-Urology

CiteScore

2.10

自引率

0.00%

发文量

期刊介绍： The aim of the Turkish Journal of Urology is to contribute to the literature by publishing scientifically high-quality research articles as well as reviews, editorials, letters to the editor and case reports. The journal’s target audience includes, urology specialists, medical specialty fellows and other specialists and practitioners who are interested in the field of urology.