孟加拉国多囊卵巢综合征青少年的临床、代谢和激素概况

TouchREVIEWS in endocrinology Pub Date : 2021-04-01 Epub Date: 2021-04-28 DOI:10.17925/EE.2021.17.1.54
Abm Kamrul-Hasan, Fatema Tuz Zahura Aalpona, Shahjada Selim
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引用次数: 4

摘要

背景:青春期少女和成年女性多囊卵巢综合征(PCOS)的特征差异很大。多囊卵巢综合征的一些特征可能与女孩正常青春期发育的特征重叠。方法:本横断面研究在孟加拉国一家三级医院新诊断为多囊卵巢综合征的青少年中进行。对175名参与者的相关临床、代谢和激素状况进行了评估。结果:研究参与者的平均年龄为16.8(±1.7)岁。经期不调以少经为主(88%)。超过四分之一(27.4%)的参与者有一级亲属患有多囊卵巢综合征,12%的参与者有一级亲属患有2型糖尿病。超过四分之三(77.7%)的人患有黑棘皮病。大多数人(69.1%)超重(29.7%)或肥胖(39.4%),而体重不足(6.3%)。腹部肥胖占65.7%。五分之一(20%)的参与者有高血压前期,3.4%的参与者有高血压。大约四分之一(24%)的患者有糖耐量异常(糖尿病前期21.1%,糖尿病2.9%),大多数(90.9%)有血脂异常。Ferriman-Gallwey评分中位数为12,94.9%的参与者有多毛症,33.7%的参与者有生化性高雄激素症。42.3%的参与者存在代谢综合征。较高的身体质量指数和多毛症的存在与较高的代谢综合征风险相关。结论:孟加拉国多囊卵巢综合征青少年的临床、代谢和激素特征突出了危险因素,需要对代谢性疾病保持临床警惕。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Clinical, Metabolic and Hormonal Profiles of Bangladeshi Adolescents with Polycystic Ovary Syndrome.

Background: The features of polycystic ovary syndrome (PCOS) vary greatly among adolescent girls and adult women. Some of the features of PCOS may overlap with features of normal pubertal development in girls. Methods: This cross-sectional study was conducted among adolescents newly diagnosed with PCOS attending a tertiary hospital in Bangladesh. The relevant clinical, metabolic and hormonal profiles of 175 participants were evaluated. Results: The mean age of the study participants was 16.8 (±1.7) years. Oligomenorrhea was the predominant menstrual irregularity (88%). More than one-quarter of participants (27.4%) had a first-degree relative with PCOS, and 12% had a first-degree relative with type 2 diabetes. More than three-quarters (77.7%) had acanthosis nigricans. The majority (69.1%) were overweight (29.7%) or obese (39.4%), whereas 6.3% were underweight. A total of 65.7% had abdominal obesity. One-fifth (20%) of participants had pre-hypertension, and 3.4% were hypertensive. Around one-quarter (24%) had abnormal glucose tolerance (prediabetes 21.1%, diabetes 2.9%) and the majority (90.9%) had dyslipidaemia. The median Ferriman-Gallwey score was 12, 94.9% of participants had hirsutism and 33.7% had biochemical hyperandrogenism. Metabolic syndrome was present in 42.3% of participants. Higher body mass index and presence of hirsutism were associated with higher risks of metabolic syndrome. Conclusions: The clinical, metabolic and hormonal profiles of Bangladeshi adolescents with PCOS highlight risk factors and the need for clinical vigilance with respect to metabolic disease.

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