药物发现中的有机金属化合物:过去、现在和未来

Q1 Pharmacology, Toxicology and Pharmaceutics

Drug Discovery Today: Technologies Pub Date : 2020-12-01 DOI:10.1016/j.ddtec.2019.06.001

Yih Ching Ong, Gilles Gasser

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引用次数: 24

摘要

在这篇综述中，我们概述了一些过去使用过的或目前正在临床试验中的与医学相关的有机金属药物，以及目前处于药物开发初始阶段的化合物的例子。本文选择了三大类有机金属配合物进行讨论:抗菌有机砷化合物、抗疟疾和抗癌含二茂铁化合物和抗癌催化有机金属配合物。这篇综述的目的是为读者提供这些各自医学领域取得的重大进展的重点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Organometallic compounds in drug discovery: Past, present and future

In this review, we present an overview of some of the medicinally-relevant organometallic drugs that have been used in the past or that are currently in clinical trials as well as an example of compounds that are currently in the initial stage of drug development. Three main classes of organometallic complexes have been chosen for discussion: antimicrobial organoarsenicals, antimalarial and anticancer ferrocene-containing compounds and anticancer catalytic organometallic complexes. The purpose of this review is to provide readers with a focus on the significant progress that has been made for each of these respective fields of medicine.

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来源期刊

Drug Discovery Today: Technologies Pharmacology, Toxicology and Pharmaceutics-Drug Discovery

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期刊介绍： Discovery Today: Technologies compares different technological tools and techniques used from the discovery of new drug targets through to the launch of new medicines.