In-Song Lee, Jun-Ho Chang, Dae-Won Kim, Seong-Gon Kim, Tae-Woo Kim
{"title":"4-己基间苯二酚对Saos-2细胞NAD+水平和SIRT活性的影响。","authors":"In-Song Lee, Jun-Ho Chang, Dae-Won Kim, Seong-Gon Kim, Tae-Woo Kim","doi":"10.1186/s40902-021-00326-2","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>4-hexylresorcinol (4HR) has been shown to have anti-oxidant activity similar to that of resveratrol. As resveratrol increases sirtuin (SIRT) activity, 4HR might behave similarly to resveratrol.</p><p><strong>Method: </strong>In this study, the expression levels of SIRT1, SIRT3, and SIRT6 were evaluated after 4HR administration (1-100 μM). As NAD+ is a substrate for SIRTs, its levels with SIRT activity were also studied.</p><p><strong>Results: </strong>In the results, SIRT3 (100 μM at 24 h) and SIRT6 (1-100 μM at 24 h and 10 μM at 8 h) were shown to have significantly higher expression levels compared to untreated control (p < 0.05). Pan-SIRT activity and the NAD+ level was significantly increased compared to that of the untreated control (p < 0.05; 10 and 100 μM at 24 h).</p><p><strong>Conclusion: </strong>4HR administration increased SIRT activity and the NAD+ level in Saos-2 cells.</p>","PeriodicalId":18357,"journal":{"name":"Maxillofacial Plastic and Reconstructive Surgery","volume":"43 1","pages":"39"},"PeriodicalIF":2.0000,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8558123/pdf/","citationCount":"3","resultStr":"{\"title\":\"The effect of 4-hexylresorinol administration on NAD+ level and SIRT activity in Saos-2 cells.\",\"authors\":\"In-Song Lee, Jun-Ho Chang, Dae-Won Kim, Seong-Gon Kim, Tae-Woo Kim\",\"doi\":\"10.1186/s40902-021-00326-2\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>4-hexylresorcinol (4HR) has been shown to have anti-oxidant activity similar to that of resveratrol. As resveratrol increases sirtuin (SIRT) activity, 4HR might behave similarly to resveratrol.</p><p><strong>Method: </strong>In this study, the expression levels of SIRT1, SIRT3, and SIRT6 were evaluated after 4HR administration (1-100 μM). As NAD+ is a substrate for SIRTs, its levels with SIRT activity were also studied.</p><p><strong>Results: </strong>In the results, SIRT3 (100 μM at 24 h) and SIRT6 (1-100 μM at 24 h and 10 μM at 8 h) were shown to have significantly higher expression levels compared to untreated control (p < 0.05). Pan-SIRT activity and the NAD+ level was significantly increased compared to that of the untreated control (p < 0.05; 10 and 100 μM at 24 h).</p><p><strong>Conclusion: </strong>4HR administration increased SIRT activity and the NAD+ level in Saos-2 cells.</p>\",\"PeriodicalId\":18357,\"journal\":{\"name\":\"Maxillofacial Plastic and Reconstructive Surgery\",\"volume\":\"43 1\",\"pages\":\"39\"},\"PeriodicalIF\":2.0000,\"publicationDate\":\"2021-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8558123/pdf/\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Maxillofacial Plastic and Reconstructive Surgery\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1186/s40902-021-00326-2\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"DENTISTRY, ORAL SURGERY & MEDICINE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Maxillofacial Plastic and Reconstructive Surgery","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1186/s40902-021-00326-2","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}
The effect of 4-hexylresorinol administration on NAD+ level and SIRT activity in Saos-2 cells.
Background: 4-hexylresorcinol (4HR) has been shown to have anti-oxidant activity similar to that of resveratrol. As resveratrol increases sirtuin (SIRT) activity, 4HR might behave similarly to resveratrol.
Method: In this study, the expression levels of SIRT1, SIRT3, and SIRT6 were evaluated after 4HR administration (1-100 μM). As NAD+ is a substrate for SIRTs, its levels with SIRT activity were also studied.
Results: In the results, SIRT3 (100 μM at 24 h) and SIRT6 (1-100 μM at 24 h and 10 μM at 8 h) were shown to have significantly higher expression levels compared to untreated control (p < 0.05). Pan-SIRT activity and the NAD+ level was significantly increased compared to that of the untreated control (p < 0.05; 10 and 100 μM at 24 h).
Conclusion: 4HR administration increased SIRT activity and the NAD+ level in Saos-2 cells.
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