核苷酸类似物抑制病毒RNA复制的机制。

Q3 Biochemistry, Genetics and Molecular Biology

Enzymes Pub Date : 2021-01-01 Epub Date: 2021-09-27 DOI:10.1016/bs.enz.2021.07.001

Kenneth A Johnson, Tyler Dangerfield

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引用次数: 7

摘要

核苷酸类似物是用于控制RNA病毒感染的直接作用抗病毒药物的基础。在这里，我们回顾了现有的核苷酸/核苷类似物以及RNA和DNA复制的动力学和机制，重点介绍了SARS-CoV-2 RNA依赖性RNA聚合酶(RdRp)与HIV逆转录酶和丙型肝炎RdRp的比较。我们展示了精确的动力学分析如何揭示惊人的结果来解释抗病毒核苷类似物的有效性，为设计新的抑制剂提供指导。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Mechanisms of inhibition of viral RNA replication by nucleotide analogs.

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Mechanisms of inhibition of viral RNA replication by nucleotide analogs.

Nucleotide analogs are the cornerstone of direct acting antivirals used to control infection by RNA viruses. Here we review what is known about existing nucleotide/nucleoside analogs and the kinetics and mechanisms of RNA and DNA replication, with emphasis on the SARS-CoV-2 RNA dependent RNA polymerase (RdRp) in comparison to HIV reverse transcriptase and Hepatitis C RdRp. We demonstrate how accurate kinetic analysis reveals surprising results to explain the effectiveness of antiviral nucleoside analogs providing guidelines for the design of new inhibitors.

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来源期刊

Enzymes Biochemistry, Genetics and Molecular Biology-Biotechnology

CiteScore

4.30

自引率

0.00%

发文量