纳米生物表面相互作用,癌细胞的细胞内化和纳米材料的电子数据门户:综述。

IF 3.8 4区 工程技术 Q1 BIOCHEMICAL RESEARCH METHODS
IET nanobiotechnology Pub Date : 2021-08-01 Epub Date: 2021-03-22 DOI:10.1049/nbt2.12040
Ram Dhan Yadav, Abha Chaudhary
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引用次数: 1

摘要

纳米材料在电子、能源、环境工业、生物传感器、纳米器件、治疗平台等领域有着广泛的应用。纳米颗粒可以增加载药材料的溶解度和稳定性,增强其内化,保护它们免受生物系统中的初始破坏,并延长其循环时间。体液中存在的蛋白质与纳米颗粒的生物相互作用可以改变纳米颗粒的活性和自然表面性质。纳米颗粒的大小和电荷、包被和未包被纳米颗粒的性质、蛋白质的性质、细胞相互作用指导了它们在细胞系统中的内化途径。因此,本综述强调了包被的、未包被的纳米颗粒、大小和电荷、蛋白质的性质对纳米生物表面相互作用和内化的影响,并特别关注癌细胞。NPs活性的增加也可能对健康和环境产生毒性,因此在医学领域应重视NPs的毒性评估。本文还讨论了纳米材料的电子数据共享门户,这将有助于提供纳米材料的化学、物理、生物特性和毒性方面的信息。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Nano-bio surface interactions, cellular internalisation in cancer cells and e-data portals of nanomaterials: A review.

Nano-bio surface interactions, cellular internalisation in cancer cells and e-data portals of nanomaterials: A review.

Nano-bio surface interactions, cellular internalisation in cancer cells and e-data portals of nanomaterials: A review.

Nano-bio surface interactions, cellular internalisation in cancer cells and e-data portals of nanomaterials: A review.

Nanomaterials (NMs) have abundant applications in areas such as electronics, energy, environment industries, biosensors, nano devices, theranostic platforms, etc. Nanoparticles can increase the solubility and stability of drug-loaded materials, enhance their internalisation, protect them from initial destruction in the biological system, and lengthen their circulation time. The biological interaction of proteins present in the body fluid with NMs can change the activity and natural surface properties of NMs. The size and charge of NMs, properties of the coated and uncoated NMs, nature of proteins, cellular interactions direct their internalisation pathway in the cellular system. Thus, the present review emphasises the impact of coated, uncoated NMs, size and charge, nature of proteins on nano-bio surface interactions and on internalisation with specific focus on cancer cells. The increased activity of NPs may also result in toxicity on health and environment, thus emphasis should be given to assess the toxicity of NMs in the medical field. The e-data sharing portals of NMs have also been discussed in this review that will be helpful in providing the information about the chemical, physical, biological properties and toxicity of NMs.

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来源期刊
IET nanobiotechnology
IET nanobiotechnology 工程技术-纳米科技
CiteScore
6.20
自引率
4.30%
发文量
34
审稿时长
1 months
期刊介绍: Electrical and electronic engineers have a long and illustrious history of contributing new theories and technologies to the biomedical sciences. This includes the cable theory for understanding the transmission of electrical signals in nerve axons and muscle fibres; dielectric techniques that advanced the understanding of cell membrane structures and membrane ion channels; electron and atomic force microscopy for investigating cells at the molecular level. Other engineering disciplines, along with contributions from the biological, chemical, materials and physical sciences, continue to provide groundbreaking contributions to this subject at the molecular and submolecular level. Our subject now extends from single molecule measurements using scanning probe techniques, through to interactions between cells and microstructures, micro- and nano-fluidics, and aspects of lab-on-chip technologies. The primary aim of IET Nanobiotechnology is to provide a vital resource for academic and industrial researchers operating in this exciting cross-disciplinary activity. We can only achieve this by publishing cutting edge research papers and expert review articles from the international engineering and scientific community. To attract such contributions we will exercise a commitment to our authors by ensuring that their manuscripts receive rapid constructive peer opinions and feedback across interdisciplinary boundaries. IET Nanobiotechnology covers all aspects of research and emerging technologies including, but not limited to: Fundamental theories and concepts applied to biomedical-related devices and methods at the micro- and nano-scale (including methods that employ electrokinetic, electrohydrodynamic, and optical trapping techniques) Micromachining and microfabrication tools and techniques applied to the top-down approach to nanobiotechnology Nanomachining and nanofabrication tools and techniques directed towards biomedical and biotechnological applications (e.g. applications of atomic force microscopy, scanning probe microscopy and related tools) Colloid chemistry applied to nanobiotechnology (e.g. cosmetics, suntan lotions, bio-active nanoparticles) Biosynthesis (also known as green synthesis) of nanoparticles; to be considered for publication, research papers in this area must be directed principally towards biomedical research and especially if they encompass in vivo models or proofs of concept. We welcome papers that are application-orientated or offer new concepts of substantial biomedical importance Techniques for probing cell physiology, cell adhesion sites and cell-cell communication Molecular self-assembly, including concepts of supramolecular chemistry, molecular recognition, and DNA nanotechnology Societal issues such as health and the environment Special issues. Call for papers: Smart Nanobiosensors for Next-generation Biomedical Applications - https://digital-library.theiet.org/files/IET_NBT_CFP_SNNBA.pdf Selected extended papers from the International conference of the 19th Asian BioCeramic Symposium - https://digital-library.theiet.org/files/IET_NBT_CFP_ABS.pdf
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