1047例食管鳞癌根治性切除术患者血清预处理CYFRA水平对预后的影响:一项日本食管学会促进研究

IF 1.1 4区 医学 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS
Nobuki Ishioka, Takashi Suzuki, Satoshi Yajima, Kentaro Murakami, Yu Ohkura, Takashi Fukuda, Koichi Yagi, Akihiko Okamura, Isamu Hoshino, Chikara Kunisaki, Yasuaki Nakajima, Kosuke Narumiya, Ryo Ogawa, Hideaki Shimada
{"title":"1047例食管鳞癌根治性切除术患者血清预处理CYFRA水平对预后的影响:一项日本食管学会促进研究","authors":"Nobuki Ishioka,&nbsp;Takashi Suzuki,&nbsp;Satoshi Yajima,&nbsp;Kentaro Murakami,&nbsp;Yu Ohkura,&nbsp;Takashi Fukuda,&nbsp;Koichi Yagi,&nbsp;Akihiko Okamura,&nbsp;Isamu Hoshino,&nbsp;Chikara Kunisaki,&nbsp;Yasuaki Nakajima,&nbsp;Kosuke Narumiya,&nbsp;Ryo Ogawa,&nbsp;Hideaki Shimada","doi":"10.5761/atcs.oa.21-00195","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>The prognostic significance of pretreatment serum C-terminus of cytokeratin 19 (CYFRA21-1, CYFRA) status was evaluated in the patients with surgically treated esophageal squamous cell carcinoma.</p><p><strong>Methods: </strong>A total of 1047 patients with surgically treated esophageal cancer were enrolled in a multi-institutional study promoted by the Japanese Esophageal Society. This study included an up-front surgery group (n = 412), a neoadjuvant chemotherapy (NAC) group (n = 486), and a neoadjuvant chemoradiation/radiation therapy (NACRT/RT) group (n = 149). The pretreatment CYFRA status was analyzed to assess prognostic significance using multivariate analysis according to treatment modalities.</p><p><strong>Results: </strong>The CYFRA-positive group was significantly associated with deep tumor. Univariate analysis showed that the overall survival of the CYFRA-positive group was significantly worse than that of the CYFRA-negative group, but the difference was not significant in the multivariate analysis. CYFRA was an independent risk factor for poor prognosis just in the NACRT/RT group.</p><p><strong>Conclusions: </strong>The CYFRA-positive group was associated with deep tumor and poor survival. Pretreatment CYFRA was not an independent risk factor for poor prognosis in the up-front surgery group or NAC group. It was an independent risk factor for poor prognosis just in the NACRT/RT group.</p>","PeriodicalId":8037,"journal":{"name":"Annals of Thoracic and Cardiovascular Surgery","volume":"28 3","pages":"163-170"},"PeriodicalIF":1.1000,"publicationDate":"2022-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d6/11/atcs-28-163.PMC9209890.pdf","citationCount":"1","resultStr":"{\"title\":\"Prognostic Impact of Pretreatment Serum CYFRA Status in 1047 Patients with Esophageal Squamous Cell Carcinoma Who Underwent Radical Resection: A Japan Esophageal Society Promotion Research.\",\"authors\":\"Nobuki Ishioka,&nbsp;Takashi Suzuki,&nbsp;Satoshi Yajima,&nbsp;Kentaro Murakami,&nbsp;Yu Ohkura,&nbsp;Takashi Fukuda,&nbsp;Koichi Yagi,&nbsp;Akihiko Okamura,&nbsp;Isamu Hoshino,&nbsp;Chikara Kunisaki,&nbsp;Yasuaki Nakajima,&nbsp;Kosuke Narumiya,&nbsp;Ryo Ogawa,&nbsp;Hideaki Shimada\",\"doi\":\"10.5761/atcs.oa.21-00195\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>The prognostic significance of pretreatment serum C-terminus of cytokeratin 19 (CYFRA21-1, CYFRA) status was evaluated in the patients with surgically treated esophageal squamous cell carcinoma.</p><p><strong>Methods: </strong>A total of 1047 patients with surgically treated esophageal cancer were enrolled in a multi-institutional study promoted by the Japanese Esophageal Society. This study included an up-front surgery group (n = 412), a neoadjuvant chemotherapy (NAC) group (n = 486), and a neoadjuvant chemoradiation/radiation therapy (NACRT/RT) group (n = 149). The pretreatment CYFRA status was analyzed to assess prognostic significance using multivariate analysis according to treatment modalities.</p><p><strong>Results: </strong>The CYFRA-positive group was significantly associated with deep tumor. Univariate analysis showed that the overall survival of the CYFRA-positive group was significantly worse than that of the CYFRA-negative group, but the difference was not significant in the multivariate analysis. CYFRA was an independent risk factor for poor prognosis just in the NACRT/RT group.</p><p><strong>Conclusions: </strong>The CYFRA-positive group was associated with deep tumor and poor survival. Pretreatment CYFRA was not an independent risk factor for poor prognosis in the up-front surgery group or NAC group. It was an independent risk factor for poor prognosis just in the NACRT/RT group.</p>\",\"PeriodicalId\":8037,\"journal\":{\"name\":\"Annals of Thoracic and Cardiovascular Surgery\",\"volume\":\"28 3\",\"pages\":\"163-170\"},\"PeriodicalIF\":1.1000,\"publicationDate\":\"2022-06-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d6/11/atcs-28-163.PMC9209890.pdf\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Annals of Thoracic and Cardiovascular Surgery\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.5761/atcs.oa.21-00195\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2022/6/17 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q4\",\"JCRName\":\"CARDIAC & CARDIOVASCULAR SYSTEMS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annals of Thoracic and Cardiovascular Surgery","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.5761/atcs.oa.21-00195","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2022/6/17 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
引用次数: 1

摘要

目的:探讨术前血清c -末端细胞角蛋白19 (CYFRA21-1, CYFRA)水平对食管鳞癌患者预后的影响。方法:共有1047例手术治疗的食管癌患者参加了一项由日本食管学会推动的多机构研究。本研究包括前期手术组(n = 412)、新辅助化疗组(n = 486)和新辅助放化疗/放疗组(n = 149)。根据治疗方式,采用多因素分析分析预处理CYFRA状态,评估预后意义。结果:cyfr阳性组与深部肿瘤有显著相关性。单因素分析显示,cyfr -阳性组的总生存率明显差于cyfr -阴性组,但多因素分析差异无统计学意义。仅在NACRT/RT组中,CYFRA是预后不良的独立危险因素。结论:cyfr阳性组与深部肿瘤相关,生存期较差。预处理CYFRA在前期手术组和NAC组均不是预后不良的独立危险因素。仅在NACRT/RT组中,它是预后不良的独立危险因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Prognostic Impact of Pretreatment Serum CYFRA Status in 1047 Patients with Esophageal Squamous Cell Carcinoma Who Underwent Radical Resection: A Japan Esophageal Society Promotion Research.

Prognostic Impact of Pretreatment Serum CYFRA Status in 1047 Patients with Esophageal Squamous Cell Carcinoma Who Underwent Radical Resection: A Japan Esophageal Society Promotion Research.

Prognostic Impact of Pretreatment Serum CYFRA Status in 1047 Patients with Esophageal Squamous Cell Carcinoma Who Underwent Radical Resection: A Japan Esophageal Society Promotion Research.

Purpose: The prognostic significance of pretreatment serum C-terminus of cytokeratin 19 (CYFRA21-1, CYFRA) status was evaluated in the patients with surgically treated esophageal squamous cell carcinoma.

Methods: A total of 1047 patients with surgically treated esophageal cancer were enrolled in a multi-institutional study promoted by the Japanese Esophageal Society. This study included an up-front surgery group (n = 412), a neoadjuvant chemotherapy (NAC) group (n = 486), and a neoadjuvant chemoradiation/radiation therapy (NACRT/RT) group (n = 149). The pretreatment CYFRA status was analyzed to assess prognostic significance using multivariate analysis according to treatment modalities.

Results: The CYFRA-positive group was significantly associated with deep tumor. Univariate analysis showed that the overall survival of the CYFRA-positive group was significantly worse than that of the CYFRA-negative group, but the difference was not significant in the multivariate analysis. CYFRA was an independent risk factor for poor prognosis just in the NACRT/RT group.

Conclusions: The CYFRA-positive group was associated with deep tumor and poor survival. Pretreatment CYFRA was not an independent risk factor for poor prognosis in the up-front surgery group or NAC group. It was an independent risk factor for poor prognosis just in the NACRT/RT group.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Annals of Thoracic and Cardiovascular Surgery
Annals of Thoracic and Cardiovascular Surgery CARDIAC & CARDIOVASCULAR SYSTEMS-SURGERY
CiteScore
2.80
自引率
0.00%
发文量
56
审稿时长
4-8 weeks
期刊介绍: Information not localized
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信