光甘草定与诺氟沙星协同作用诱导多重耐药金黄色葡萄球菌ROS。

IF 0.8 4区生物学 Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Journal of General and Applied Microbiology Pub Date : 2021-12-31 Epub Date: 2021-10-23 DOI:10.2323/jgam.2021.06.002

Vigyasa Singh, Anirban Pal, Mahendra P Darokar

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引用次数: 4

摘要

光甘草定(Glb)是一种多酚类黄酮，通过诱导ROS抑制耐多药金黄色葡萄球菌(MDRSA) 4627的生长。Glb联合诺氟沙星(Nor)协同诱导氧化应激。特别是ROS/RNS水平的增加，影响了大分子(DNA、脂质、蛋白质)的完整性，扭曲了细胞形态。我们发现药物效应与氧化应激相关基因和耐多药基因的上调/下调存在相关性。这些发现可以大大增强Nor与Glb联合给药的常规，Glb作为抗金黄色葡萄球菌的抗菌剂具有很好的前景。

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Glabridin synergy with norfloxacin induces ROS in multidrug resistant Staphylococcus aureus.

Glabridin (Glb), a polyphenolic flavonoid inhibits the growth of MDRSA (Multidrug resistant S. aureus) 4627 by inducing ROS. Glb in combination with Norfloxacin (Nor) synergistically induced oxidative stress. Increased ROS/RNS levels, in particular, affected macromolecules' (DNA, lipid, protein) integrity and distorted cell morphology. We found correlation between drug-effects and up-/down-regulation of oxidative stress-related as well as MDR genes. These findings could considerably potentiate the dosing routine of Nor in combination with Glb, which holds a promising prospective as a antibacterial agent against S. aureus.

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来源期刊

Journal of General and Applied Microbiology 生物-生物工程与应用微生物

CiteScore

2.40

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： JGAM is going to publish scientific reports containing novel and significant microbiological findings, which are mainly devoted to the following categories: Antibiotics and Secondary Metabolites; Biotechnology and Metabolic Engineering; Developmental Microbiology; Environmental Microbiology and Bioremediation; Enzymology; Eukaryotic Microbiology; Evolution and Phylogenetics; Genome Integrity and Plasticity; Microalgae and Photosynthesis; Microbiology for Food; Molecular Genetics; Physiology and Cell Surface; Synthetic and Systems Microbiology.