金盏菊治疗手部急性伤口的随机试验。

IF 3.6 Q2 MEDICINE, RESEARCH & EXPERIMENTAL
Tissue Barriers Pub Date : 2022-07-03 Epub Date: 2021-10-21 DOI:10.1080/21688370.2021.1994822
Giana Silveira Giostri, Eduardo Murilo Novak, Marcelo Buzzi, Luiz Cesar Guarita-Souza
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引用次数: 4

摘要

大多数手部和手指的损伤,特别是指髓上的损伤,适合于二次愈合。然而,上皮形成的延迟似乎不利于限制这种技术。本对照随机临床试验的目的是通过光平面测量法分析金盏菊(Calendula officinalis L., SEC)标准化提取物对手部急性伤口继发愈合过程的进展。符合条件的参与者队列包括两组20例手部和手指皮肤脱落患者,每组接受二次意向治疗。对照组(CG)使用矿物油,干预组(IG)使用SEC。每次门诊评估时拍摄伤口照片,直到上皮形成并使用ImageJ测量。干预组(IG)和对照组(CG)各有19处伤口,主要由40多岁的男性形成,食指和无名指在左侧,变量均匀,初始伤口面积相似。IG组上皮形成时间短,愈合速度快(IG = 8.6±4.7天,9.5±5.8%天,CG = 13.2±7.4天,6.2±2.9%天)
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Treatment of acute wounds in hand with <i>Calendula officinalis</i> L.: A randomized trial.

Treatment of acute wounds in hand with Calendula officinalis L.: A randomized trial.

Most injuries in the hand and fingers, especially on the digital pulps, are suited for healing by secondary intention. Nevertheless, delay in epithelization seems to unfavorably restrict this technique. The purpose of this controlled randomized clinical trial is to analyze by means of photo planimetry the progression of the healing process by secondary intention in acute wounds of the hand using the standardized extract of Calendula officinalis L. (SEC). The cohort of eligible participants included two groups of 20 patients with skin loss in the hand and fingers treated by secondary intention. Control group (CG) used mineral oil and intervention group (IG) received SEC. Wound pictures were captured at each outpatient assessment until epithelization was achieved and measured with ImageJ. Intervention group (IG) and control group (CG) with 19 wounds each, primarily formed by men in their 40's with wounds in their index and ring fingers on the left side, showed homogeneous variables and similar initial wound areas. Epithelization time was shorter and healing speed was faster in IG (IG = 8.6 ± 4.7 days and 9.5 ± 5.8%day versus CG = 13.2 ± 7.4 days and 6.2 ± 2.9%day, ƿ < 0.05), leading to the conclusion that healing by secondary intention in acute wounds of the hand and fingers with SEC led to a faster epithelization.

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来源期刊
Tissue Barriers
Tissue Barriers MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
6.60
自引率
6.50%
发文量
25
期刊介绍: Tissue Barriers is the first international interdisciplinary journal that focuses on the architecture, biological roles and regulation of tissue barriers and intercellular junctions. We publish high quality peer-reviewed articles that cover a wide range of topics including structure and functions of the diverse and complex tissue barriers that occur across tissue and cell types, including the molecular composition and dynamics of polarized cell junctions and cell-cell interactions during normal homeostasis, injury and disease state. Tissue barrier formation in regenerative medicine and restoration of tissue and organ function is also of interest. Tissue Barriers publishes several categories of articles including: Original Research Papers, Short Communications, Technical Papers, Reviews, Perspectives and Commentaries, Hypothesis and Meeting Reports. Reviews and Perspectives/Commentaries will typically be invited. We also anticipate to publish special issues that are devoted to rapidly developing or controversial areas of research. Suggestions for topics are welcome. Tissue Barriers objectives: Promote interdisciplinary awareness and collaboration between researchers working with epithelial, epidermal and endothelial barriers and to build a broad and cohesive worldwide community of scientists interesting in this exciting field. Comprehend the enormous complexity of tissue barriers and map cross-talks and interactions between their different cellular and non-cellular components. Highlight the roles of tissue barrier dysfunctions in human diseases. Promote understanding and strategies for restoration of tissue barrier formation and function in regenerative medicine. Accelerate a search for pharmacological enhancers of tissue barriers as potential therapeutic agents. Understand and optimize drug delivery across epithelial and endothelial barriers.
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