老年患者小脑脂质神经细胞瘤:DNA甲基化分析作为一种有用的诊断工具。

IF 0.8 4区医学 Q4 CLINICAL NEUROLOGY

Clinical Neuropathology Pub Date : 2022-01-01 DOI:10.5414/NP301415

Hiba Alzoubi, Francesca Gianno, Yussuf Abuelhaija, Angam Ayyoub Najadat, Ahmad Mustafa, Aws Younes Al-Arman, Lujain Younes Al-Arman, Dana Banihani, Aya Mustafa, Noor Abualdahab, Giuseppe Broggi, Gabriele Gaggero, Nataniele Piol, Pietro Fiaschi, Evelina Miele, Felice Giangaspero

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引用次数: 1

摘要

目的:小脑脂肪神经细胞瘤是一种罕见的原发性小脑肿瘤，多见于成人，但在老年人中罕见。材料和方法:我们报告一例79岁女性，既往诊断为原发性小脑肿瘤伴神经内分泌分化的复发性蛔虫性小脑肿块。复发灶表现为间变性及脂化。结果:对复发肿瘤进行DNA甲基化分析，结果显示与小脑脂质神经细胞瘤高度吻合。结论:本报告证实了DNA甲基化谱在诊断挑战性中枢神经系统肿瘤中的作用。

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Cerebellar liponeurocytoma in an elderly patient: DNA methylation profiling as a helpful diagnostic tool.

Aim: Cerebellar liponeurocytoma is a rare primary cerebellar neoplasm that mostly occurs in adults, however, it is rare in the elderly.

Materials and methods: We report, in a 79-year-old female, a recurrent vermian cerebellar mass that was previously diagnosed as primary cerebellar tumor with neuroendocrine differentiation. The recurrent lesion showed anaplastic features and lipidization.

Results: DNA methylation profiling was performed for the recurrent tumor, which showed a high score match for cerebellar liponeurocytoma.

Conclusion: This report confirms the usefulness of DNA methylation profiling for the diagnosis of challenging CNS tumors.

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来源期刊

Clinical Neuropathology 医学-病理学

CiteScore

1.60

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Clinical Neuropathology appears bi-monthly and publishes reviews and editorials, original papers, short communications and reports on recent advances in the entire field of clinical neuropathology. Papers on experimental neuropathologic subjects are accepted if they bear a close relationship to human diseases. Correspondence (letters to the editors) and current information including book announcements will also be published.