PKM2瓜氨酸化对糖酵解和癌细胞增殖的调控。

IF 2.6 Q3 ONCOLOGY

Molecular and Cellular Oncology Pub Date : 2021-06-04 eCollection Date: 2021-01-01 DOI:10.1080/23723556.2021.1927446

Sébastien Coassolo, Irwin Davidson

引用次数: 2

摘要

肽基精氨酸转化为肽基瓜氨酸，称为瓜氨酸化，是由PADI(蛋白精氨酸脱亚胺酶)家族酶催化的翻译后蛋白质修饰。PADI1和PADI3在糖酵解酶丙酮酸激酶M2中催化精氨酸106的瓜氨酸化，调节其变构调节、糖酵解和癌细胞增殖。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Regulation of glycolysis and cancer cell proliferation by PKM2 citrullination.

Conversion of peptidyl-arginine to peptidyl citrulline, known as citrullination, is a post-translational protein modification catalyzed by the PADI (Protein Arginine Deiminase) family of enzymes. PADI1 and PADI3 catalyze citrullination of arginine 106 in the glycolytic enzyme pyruvate kinase M2 modulating its allosteric regulation, glycolysis and cancer cell proliferation.

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来源期刊

Molecular and Cellular Oncology Biochemistry, Genetics and Molecular Biology-Cancer Research

CiteScore

3.20

自引率

0.00%

发文量

期刊介绍： For a long time, solid neoplasms have been viewed as relatively homogeneous entities composed for the most part of malignant cells. It is now clear that tumors are highly heterogeneous structures that evolve in the context of intimate interactions between cancer cells and endothelial, stromal as well as immune cells. During the past few years, experimental and clinical oncologists have witnessed several conceptual transitions of this type. Molecular and Cellular Oncology (MCO) emerges within this conceptual framework as a high-profile forum for the publication of fundamental, translational and clinical research on cancer. The scope of MCO is broad. Submissions dealing with all aspects of oncogenesis, tumor progression and response to therapy will be welcome, irrespective of whether they focus on solid or hematological neoplasms. MCO has gathered leading scientists with expertise in multiple areas of cancer research and other fields of investigation to constitute a large, interdisciplinary, Editorial Board that will ensure the quality of articles accepted for publication. MCO will publish Original Research Articles, Brief Reports, Reviews, Short Reviews, Commentaries, Author Views (auto-commentaries) and Meeting Reports dealing with all aspects of cancer research.