TMPRSS4过表达促进结直肠癌转移,预示III-IV期结直肠癌预后不良。

IF 2.3 4区 医学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Xue-Feng Zhao, Yu-Shen Yang, Da-Zhi Gao, Young Kyu Park
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引用次数: 3

摘要

目的:详细研究TMPRSS4在结直肠癌中的表达规律及预后意义。方法:采用Western blot法检测大肠癌组织和正常组织中TMPRSS4蛋白的表达。采用免疫组化方法检测TMPRSS4在结直肠癌组织中的表达,分析其临床病理特征及预后意义。结果:TMPRSS4过表达与肿瘤出芽、淋巴血管侵袭、神经周围侵袭、癌栓、浸润深度、淋巴结转移、远处转移、肿瘤淋巴结转移分期(P P)有关。TMPRSS4参与了结直肠癌从肿瘤出芽到淋巴结转移和/或远处转移的整个过程,并预测了III-IV期的不良预后,提示TMPRSS4是精确治疗结直肠癌淋巴结或远处器官转移的新靶点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
TMPRSS4 overexpression promotes the metastasis of colorectal cancer and predicts poor prognosis of stage III-IV colorectal cancer.

Purpose: To study in detail the expression pattern and prognostic significance of TMPRSS4 in colorectal cancer.

Methods: The expression of TMPRSS4 protein was determined using Western blot in the colorectal cancer tissues and normal tissues. Immunohistochemistry was used to detect the TMPRSS4 expression in colorectal cancer tissues, and the clinicopathologic characteristics and prognostic significance were analyzed.

Results: TMPRSS4 overexpression was associated with tumor budding, lymphovascular invasion, perineural invasion, cancerous emboli, infiltration depth, lymph node metastasis, distant metastasis, and tumor node metastasis stage (P < 0.05 for all). Interestingly, TMPRSS4 expression in the tumor budding, tumor emboli, lymph node, and liver metastatic tumor samples was higher than in the paired primary tumors. In contrast, TMPRSS4 overexpression is inversely correlated with both the overall survival and the disease-free survival of the patients with colorectal cancer (P < 0.05 for both). Also, we found that TMPRSS4 is only of significance in predicting the prognosis of stage III and IV colorectal cancer, not stage I and II.

Conclusions: TMPRSS4 was shown to be involved in the whole process of metastasis from tumor budding to lymph node and/or distant metastasis in colorectal cancer and predicted the unfavorable prognosis of stage III-IV, indicating that it is a novel target for the precise treatment of colorectal cancer with lymph node or distant organ metastasis.

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来源期刊
International Journal of Biological Markers
International Journal of Biological Markers 医学-生物工程与应用微生物
CiteScore
4.10
自引率
0.00%
发文量
43
期刊介绍: IJBM is an international, online only, peer-reviewed Journal, which publishes original research and critical reviews primarily focused on cancer biomarkers. IJBM targets advanced topics regarding the application of biomarkers in oncology and is dedicated to solid tumors in adult subjects. The clinical scenarios of interests are screening and early diagnosis of cancer, prognostic assessment, prediction of the response to and monitoring of treatment.
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