评价暴露于TiO2光催化剂(GST)的家兔潜在的眼睛或皮肤刺激/腐蚀。

Environmental analysis, health and toxicology Pub Date : 2021-09-01 Epub Date: 2021-09-28 DOI:10.5620/eaht.2021022
Sang Ho Kim, Myeong Kyu Park, Ja Kyung Seol, Jae Min Im, Hae Sung Park, Heung Sik Seo, Hee Ju Park, Sung Soon Nah
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引用次数: 5

摘要

TiO2 NPs光催化剂广泛应用于环境和能源领域的各种应用和产品中,包括自清洁表面、空气和水净化系统、杀菌、析氢和光电化学转化。TiO2皮肤暴露和吸收可能产生的生物和安全影响尚未得到很好的研究,需要对TiO2的潜在健康危害进行更多的调查。本研究旨在根据OECD测试指南(TG 404405)和成像评估(微型计算机断层扫描分析)、组织病理学检查,研究新TiO2材料粉末、污水处理厂污泥回收产生的GST的局部损伤(眼睛和皮肤刺激/腐蚀)的潜在影响。此外,使用商业光催化剂P-25与GST进行比较。对于眼睛或皮肤刺激/腐蚀测试,测试物质(GST,P-25)显示局部损伤没有刺激/腐蚀,GHS类别被确定为“无危险类别”。影像学分析表明,GST没有渗透或分布在局部病变(眼睛、皮肤)中,在组织病理学中也没有观察到与治疗相关的效果。因此,本研究表明,新型TiO2粉末GST被认为在局部病变(眼睛、皮肤)中没有潜在影响(刺激/腐蚀)、渗透或分布。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Evaluation of potential eye or skin irritation/corrosion in rabbit exposed to TiO2 photocatalyst (GST).

Evaluation of potential eye or skin irritation/corrosion in rabbit exposed to TiO2 photocatalyst (GST).

Evaluation of potential eye or skin irritation/corrosion in rabbit exposed to TiO2 photocatalyst (GST).

Evaluation of potential eye or skin irritation/corrosion in rabbit exposed to TiO2 photocatalyst (GST).

TiO2 NPs photocatalyst is widely used in a variety of applications and products in the environmental and energy fields, including self-cleaning surfaces, air and water purification systems, sterilization, hydrogen evolution, and photoelectrochemical conversion. The possible biological and safety effects of TiO2 dermal exposure and absorption have not been well studied and more investigations on the potential health hazards of the TiO2 are needed. This study aimed to investigate potential effect of local lesions (eye and skin irritation/corrosion) for new TiO2 material powder, GST produced through sludge recycling of the sewage treatment plant in according to the OECD test guideline (TG 404, 405) and imaging evaluation (micro-computed tomography analysis), histopathology examination. Also, P-25, commercial photocatalyst was used to compare with GST. For the eye or skin irritation/corrosion test, the test substances (GST, P-25) showed no irritation/corrosion for local lesions and the GHS category was identified as a "No hazard class". The imaging analysis indicated that GST did not penetrate or distribute in the local lesions (eye, skin) and the treatment-related effect was not observed in histopathology. Therefore, the present study revealed that new TiO2 powder, GST was considered to be no potential effects (irritation/corrosion), penetration or distribution in the local lesions (eye, skin).

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