{"title":"伊朗首次从真菌性中耳炎中分离出耐氟康唑耳念珠菌。","authors":"Mojtaba Taghizadeh Armaki, Saeid Mahdavi Omran, Keyvan Kiakojuri, Shaghayegh Khojasteh, Jalal Jafarzadeh, Mahin Tavakoli, Hamid Badali, Iman Haghani, Tahereh Shokohi, Mohammad Taghi Hedayati, Mahdi Abastabar","doi":"10.18502/cmm.7.1.6243","DOIUrl":null,"url":null,"abstract":"<p><strong>Background and purpose: </strong><i>Candida auris</i>, as a new characterized pathogenic yeast, has attracted remarkable attention in the recent decade due to its rapid global emergence and multidrug resistance traits. This unique species is able to cause nosocomial outbreaks and tolerate adverse conditions; however, it has been mostly misidentified by conventional methods.</p><p><strong>Case report: </strong>This report aimed to describe the first fluconazole-resistant case of <i>C. auris</i> otitis in an immunocompetent patient in Iran. The isolate showed minimum inhibitory concentration of ≥ 32 μg/ml for fluconazole; however, the patient was treated with topical clotrimazole and miconazole with no recurrence.</p><p><strong>Conclusion: </strong>This was the second strain of <i>C. auris</i> isolated from otitis in Iran which was fluconazole-resistant, unlike the first Iranian isolate.</p>","PeriodicalId":10863,"journal":{"name":"Current Medical Mycology","volume":"7 1","pages":"51-54"},"PeriodicalIF":0.0000,"publicationDate":"2021-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8443880/pdf/","citationCount":"15","resultStr":"{\"title\":\"First fluconazole-resistant <i>Candida auris</i> isolated from fungal otitis in Iran.\",\"authors\":\"Mojtaba Taghizadeh Armaki, Saeid Mahdavi Omran, Keyvan Kiakojuri, Shaghayegh Khojasteh, Jalal Jafarzadeh, Mahin Tavakoli, Hamid Badali, Iman Haghani, Tahereh Shokohi, Mohammad Taghi Hedayati, Mahdi Abastabar\",\"doi\":\"10.18502/cmm.7.1.6243\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background and purpose: </strong><i>Candida auris</i>, as a new characterized pathogenic yeast, has attracted remarkable attention in the recent decade due to its rapid global emergence and multidrug resistance traits. This unique species is able to cause nosocomial outbreaks and tolerate adverse conditions; however, it has been mostly misidentified by conventional methods.</p><p><strong>Case report: </strong>This report aimed to describe the first fluconazole-resistant case of <i>C. auris</i> otitis in an immunocompetent patient in Iran. The isolate showed minimum inhibitory concentration of ≥ 32 μg/ml for fluconazole; however, the patient was treated with topical clotrimazole and miconazole with no recurrence.</p><p><strong>Conclusion: </strong>This was the second strain of <i>C. auris</i> isolated from otitis in Iran which was fluconazole-resistant, unlike the first Iranian isolate.</p>\",\"PeriodicalId\":10863,\"journal\":{\"name\":\"Current Medical Mycology\",\"volume\":\"7 1\",\"pages\":\"51-54\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2021-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8443880/pdf/\",\"citationCount\":\"15\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Current Medical Mycology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.18502/cmm.7.1.6243\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Medical Mycology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.18502/cmm.7.1.6243","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}
First fluconazole-resistant Candida auris isolated from fungal otitis in Iran.
Background and purpose: Candida auris, as a new characterized pathogenic yeast, has attracted remarkable attention in the recent decade due to its rapid global emergence and multidrug resistance traits. This unique species is able to cause nosocomial outbreaks and tolerate adverse conditions; however, it has been mostly misidentified by conventional methods.
Case report: This report aimed to describe the first fluconazole-resistant case of C. auris otitis in an immunocompetent patient in Iran. The isolate showed minimum inhibitory concentration of ≥ 32 μg/ml for fluconazole; however, the patient was treated with topical clotrimazole and miconazole with no recurrence.
Conclusion: This was the second strain of C. auris isolated from otitis in Iran which was fluconazole-resistant, unlike the first Iranian isolate.
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