方法:建立和评价人类肾脏疾病斑马鱼模型。

IF 1 4区生物学 Q4 DEVELOPMENTAL BIOLOGY

International Journal of Developmental Biology Pub Date : 2021-01-01 DOI:10.1387/ijdb.210041rs

Sana Fatma, Usharani Nayak, Rajeeb K Swain

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引用次数: 6

摘要

肾脏相关疾病影响着全世界数百万人。一项对慢性肾脏病(CKD)患者的调查显示，肾脏疾病的负担每年都在增加。2017年全球疾病负担(GBD)研究将CKD列为全球第12大死亡原因。因此，确定肾脏疾病的病因，发展准确的诊断方法和新的治疗方法是高度相关的。模式生物忠实地概括了人类疾病，在理解疾病过程中发挥着重要作用，并为找到治疗方法提供了宝贵的基础。斑马鱼是研究人类肾脏疾病发生、病理生理和分子方面的良好模型。在这篇综述中，我们总结了各种可以在斑马鱼中进行的遗传和实验操作，以更好地了解人类肾脏疾病的病理生理。我们认为这些方法将有助于开发治疗肾脏疾病的潜在疗法。

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Methods to generate and evaluate zebrafish models of human kidney diseases.

Kidney-related disorders affect millions of people worldwide. A survey of chronic kidney disease (CKD) patients showed that the burden of kidney diseases is increasing every year. The global burden of disease (GBD) study 2017 ranked CKD as the 12^th leading cause of deaths worldwide. Hence, identification of the causes of kidney diseases, development of accurate diagnostic methods and novel therapeutics is highly relevant. Model organisms that faithfully recapitulate human diseases play important roles in understanding the disease process and provide valuable ground to find their cure. Zebrafish is an excellent model to study the development, pathophysiology and molecular aspects of human kidney diseases. In this review, we summarize various genetic and experimental manipulations that can be carried out in zebrafish to better understand the pathophysiology of human kidney diseases. We suggest that these methods will be helpful in the development of potential therapies to treat kidney diseases.

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来源期刊

International Journal of Developmental Biology 生物-发育生物学

CiteScore

1.90

自引率

0.00%

发文量

审稿时长

2 months

期刊介绍： The International Journal of Developmental Biology (ISSN: 0214- 6282) is an independent, not for profit scholarly journal, published by scientists, for scientists. The journal publishes papers which throw light on our understanding of animal and plant developmental mechanisms in health and disease and, in particular, research which elucidates the developmental principles underlying stem cell properties and cancer. Technical, historical or theoretical approaches also fall within the scope of the journal. Criteria for acceptance include scientific excellence, novelty and quality of presentation of data and illustrations. Advantages of publishing in the journal include: rapid publication; free unlimited color reproduction; no page charges; free publication of online supplementary material; free publication of audio files (MP3 type); one-to-one personalized attention at all stages during the editorial process. An easy online submission facility and an open online access option, by means of which papers can be published without any access restrictions. In keeping with its mission, the journal offers free online subscriptions to academic institutions in developing countries.