合成代谢药物治疗骨质疏松诱导小模型骨形成的组织化学特征。

IF 1.3 4区 医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL
Tomomaya Yamamoto, Tomoka Hasegawa, Paulo Henrique Luiz de Fraitas, Hiromi Hongo, Shen Zhao, Tsuneyuki Yamamoto, Alireza Nasoori, Miki Abe, Haruhi Maruoka, Keisuke Kubota, Yasuhito Morimoto, Mai Haraguchi, Tomohiro Shimizu, Masahiko Takahata, Norimasa Iwasaki, Minqi Li, Norio Amizuka
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引用次数: 3

摘要

骨塑形,即骨大小和形状的改变,通常发生在发育阶段,而骨重塑——用新骨代替旧骨——主要发生在成年人身上。与骨重塑不同,骨形成是由模型,即微型模型(松质骨的微观模型)诱导的,不依赖于破骨细胞骨吸收。尽管最近开发的治疗骨质疏松的药物除了可以诱导基于重塑的骨形成外,还可以诱导基于微型模型的骨形成,但很少有报道显示基于微型模型的骨形成的组织学方面。在给予依地骨糖醇或罗莫索单抗后,与特立帕肽治疗不同,成熟的成骨细胞通过微缩模型形成新骨,而没有形成厚的成骨前层。基于微型模型的骨形成的组织学特征与重塑有很大的不同,因为它与破骨细胞骨吸收无关,导致新骨呈凸形和光滑的水泥线称为阻滞线。在这篇综述中,我们将展示由骨质疏松药物形成的基于微型模型的骨的组织学特性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Histochemical characteristics on minimodeling-based bone formation induced by anabolic drugs for osteoporotic treatment.

Modeling, the changes of bone size and shape, often takes place at the developmental stages, whereas bone remodeling-replacing old bone with new bone-predominantly occurs in adults. Unlike bone remodeling, bone formation induced by modeling i.e., minimodeling (microscopic modeling in cancellous bone) is independent of osteoclastic bone resorption. Although recently-developed drugs for osteoporotic treatment could induce minimodeling-based bone formation in addition to remodeling-based bone formation, few reports have demonstrated the histological aspects of minimodeling-based bone formation. After administration of eldecalcitol or romosozumab, unlike teriparatide treatment, mature osteoblasts formed new bone by minimodeling, without developing thick preosteoblastic layers. The histological characteristics of minimodeling-based bone formation is quite different from remodeling, as it is not related to osteoclastic bone resorption, resulting in convex-shaped new bone and smooth cement lines called arrest lines. In this review, we will show histological properties of minimodeling-based bone formation by osteoporotic drugs.

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来源期刊
Biomedical Research-tokyo
Biomedical Research-tokyo 医学-医学:研究与实验
CiteScore
2.40
自引率
0.00%
发文量
19
审稿时长
>12 weeks
期刊介绍: Biomedical Research is peer-reviewed International Research Journal . It was first launched in 1990 as a biannual English Journal and later became triannual. From 2008 it is published in Jan-Apr/ May-Aug/ Sep-Dec..
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