【新冠肺炎病理与免疫学】。

Uirusu Pub Date : 2020-01-01 DOI:10.2222/jsv.70.167
Shun Iida, Tadaki Suzuki
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引用次数: 0

摘要

自2019年12月中国武汉报告首例COVID-19病例以来,SARS-CoV-2已在全球蔓延,成为重大公共卫生问题。目前,针对COVID-19的特异性治疗正在开发中,几种对策已进入临床试验阶段。然而,这些对策的效力是有限的。为了开发有效的传染病药物或疫苗,必须通过病理分析来阐明其病因和发病机制。病理研究表明,新冠肺炎主要影响呼吸道,但也涉及其他器官。此外,免疫学研究表明,宿主免疫反应可能通过全身炎症加剧COVID-19。在这篇综述中,我们就COVID-19的病理和免疫学进行综述。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Pathology and Immunology of COVID-19].

Since the first case of COVID-19 was reported from Wuhan, China in December 2019, SARS-CoV-2 has been spreading globally and has become major public health concern. At present, development of specific treatment for COVID-19 is in progress and several countermeasures have been subjected to clinical trials. However, efficacy of these countermeasures is limited. For development of effective medicines or vaccines against infectious diseases, it is mandatory to elucidate its etiology and pathogenesis by means of pathological analysis. Pathological studies revealed that the COVID-19 mainly affects respiratory tracts although other organs are also involved. In addition, immunological studies demonstrated that host immune response may exacerbates COVID-19 through systemic inflammation. In this review, we would like to overview pathology and immunology of COVID-19.

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