长期锂治疗对肾脏的影响

IF 1.8 4区医学 Q3 CLINICAL NEUROLOGY

Human Psychopharmacology: Clinical and Experimental Pub Date : 2021-09-20 DOI:10.1002/hup.2812

M. Kâzım Yazıcı, Elçin Özçelik Eroğlu, Aygün Ertuğrul, A. Elif Anıl Yağcıoğlu, Esen Ağaoğlu, Sevilay Karahan, Nurhayat Eni, Demet Sağlam Aykut, Özlem Kavak, Yunus Erdem

引用次数: 1

摘要

目的探讨锂离子治疗对肾功能的影响及影响因素。此外，还研究了尿蛋白/肌酐比值在锂离子肾病检测中的应用。方法测定375例使用锂治疗的患者血清锂浓度、血尿素氮(BUN)、肌酐、肾小球滤过率(eGFR)及尿蛋白/肌酐比值。结果服用锂治疗≥8年的患者BUN、肌酐水平、蛋白尿百分比、2期和3期慢性肾脏疾病(CKD)百分比较高;与服用锂治疗8年的患者相比，尿密度和eGFR更低。0.8和0.6 ~ 0.8 mmol/L组尿密度低于0.6 mmol/L组。CKD的预测因子是血清中锂的含量、锂的剂量、锂的累积使用时间、发病年龄和咖啡因的摄入。结论锂用药≥8年，出现了对肾功能的不良影响。当eGFR为90 ml/min/1.73 m2时，用尿蛋白/肌酐比值测定蛋白尿也能检测到。尿蛋白/肌酐比是一种成本效益高且实用的实验室测试，可用于监测锂治疗患者。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Renal effects of long-term lithium therapy, revisited

The aim of this study was to investigate the effect of lithium treatment on renal function and to determine influencing factors. In addition, the utility of spot urine protein/creatinine ratio in detection of lithium induced nephropathy was also investigated.

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来源期刊

Human Psychopharmacology: Clinical and Experimental 医学-精神病学

CiteScore

4.10

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Human Psychopharmacology: Clinical and Experimental provides a forum for the evaluation of clinical and experimental research on both new and established psychotropic medicines. Experimental studies of other centrally active drugs, including herbal products, in clinical, social and psychological contexts, as well as clinical/scientific papers on drugs of abuse and drug dependency will also be considered. While the primary purpose of the Journal is to publish the results of clinical research, the results of animal studies relevant to human psychopharmacology are welcome. The following topics are of special interest to the editors and readers of the Journal: -All aspects of clinical psychopharmacology- Efficacy and safety studies of novel and standard psychotropic drugs- Studies of the adverse effects of psychotropic drugs- Effects of psychotropic drugs on normal physiological processes- Geriatric and paediatric psychopharmacology- Ethical and psychosocial aspects of drug use and misuse- Psychopharmacological aspects of sleep and chronobiology- Neuroimaging and psychoactive drugs- Phytopharmacology and psychoactive substances- Drug treatment of neurological disorders- Mechanisms of action of psychotropic drugs- Ethnopsychopharmacology- Pharmacogenetic aspects of mental illness and drug response- Psychometrics: psychopharmacological methods and experimental design