Juana Bautista Joyanes-Romo, Ana Isabel Navarro-Abad, José Miguel Urra-Ardanaz, Óscar González-Jiménez, Alberto Palacios, Jaime Vinicio Meneses-Sotomayor, Marta Pascual, Ma Gracia Villanueva, Davinia Garrido, Ana Joyanes, Pedro Ángel Galindo-Bonilla
{"title":"[1例儿科患者糖糖致过敏反应]。","authors":"Juana Bautista Joyanes-Romo, Ana Isabel Navarro-Abad, José Miguel Urra-Ardanaz, Óscar González-Jiménez, Alberto Palacios, Jaime Vinicio Meneses-Sotomayor, Marta Pascual, Ma Gracia Villanueva, Davinia Garrido, Ana Joyanes, Pedro Ángel Galindo-Bonilla","doi":"10.29262/ram.v658i2.876","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Sugammadex is a cyclodextrin that reverses neuromuscular blockade, especially of rocuronium. The occurrence of anaphylaxis produced by its use is of 1:1000 and 1:20000; it is observed mainly in subjects of Asian origin.</p><p><strong>Case report: </strong>A 9-year-old boy of Asian origin who, after the administration of sugammadex, immediately manifested an episode of anaphylaxis, which was reverted by using adrenaline and antihistamines. The serum tryptase at two hours was 27.7 μg/L; at 6 weeks, it was 3 μ/L. The sugammadex 100 mg/mL skin test was positive. The basophil activation test was positive with sugammadex 20 mg/mL.</p><p><strong>Conclusion: </strong>The temporal relationship between the administration of the drug, the clinical manifestations, the elevation of tryptase, and the diagnostic tests performed, disclosed the episode of anaphylaxis associated with hypersensitivity to sugammadex.</p>","PeriodicalId":21175,"journal":{"name":"Revista alergia Mexico","volume":"68 2","pages":"137-139"},"PeriodicalIF":0.0000,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":"{\"title\":\"[Anaphylaxis sugammadex-induced in a pediatric patient].\",\"authors\":\"Juana Bautista Joyanes-Romo, Ana Isabel Navarro-Abad, José Miguel Urra-Ardanaz, Óscar González-Jiménez, Alberto Palacios, Jaime Vinicio Meneses-Sotomayor, Marta Pascual, Ma Gracia Villanueva, Davinia Garrido, Ana Joyanes, Pedro Ángel Galindo-Bonilla\",\"doi\":\"10.29262/ram.v658i2.876\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>Sugammadex is a cyclodextrin that reverses neuromuscular blockade, especially of rocuronium. The occurrence of anaphylaxis produced by its use is of 1:1000 and 1:20000; it is observed mainly in subjects of Asian origin.</p><p><strong>Case report: </strong>A 9-year-old boy of Asian origin who, after the administration of sugammadex, immediately manifested an episode of anaphylaxis, which was reverted by using adrenaline and antihistamines. The serum tryptase at two hours was 27.7 μg/L; at 6 weeks, it was 3 μ/L. The sugammadex 100 mg/mL skin test was positive. The basophil activation test was positive with sugammadex 20 mg/mL.</p><p><strong>Conclusion: </strong>The temporal relationship between the administration of the drug, the clinical manifestations, the elevation of tryptase, and the diagnostic tests performed, disclosed the episode of anaphylaxis associated with hypersensitivity to sugammadex.</p>\",\"PeriodicalId\":21175,\"journal\":{\"name\":\"Revista alergia Mexico\",\"volume\":\"68 2\",\"pages\":\"137-139\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2021-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Revista alergia Mexico\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.29262/ram.v658i2.876\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Revista alergia Mexico","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.29262/ram.v658i2.876","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}
[Anaphylaxis sugammadex-induced in a pediatric patient].
Introduction: Sugammadex is a cyclodextrin that reverses neuromuscular blockade, especially of rocuronium. The occurrence of anaphylaxis produced by its use is of 1:1000 and 1:20000; it is observed mainly in subjects of Asian origin.
Case report: A 9-year-old boy of Asian origin who, after the administration of sugammadex, immediately manifested an episode of anaphylaxis, which was reverted by using adrenaline and antihistamines. The serum tryptase at two hours was 27.7 μg/L; at 6 weeks, it was 3 μ/L. The sugammadex 100 mg/mL skin test was positive. The basophil activation test was positive with sugammadex 20 mg/mL.
Conclusion: The temporal relationship between the administration of the drug, the clinical manifestations, the elevation of tryptase, and the diagnostic tests performed, disclosed the episode of anaphylaxis associated with hypersensitivity to sugammadex.
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