抑制microrna在子宫内膜异位症中的作用。

IF 1.2 4区医学 Q3 PATHOLOGY

Medical Molecular Morphology Pub Date : 2022-03-01 Epub Date: 2021-08-31 DOI:10.1007/s00795-021-00303-8

Kaei Nasu, Yoko Aoyagi, Ruofei Zhu, Mamiko Okamoto, Mitsutake Yano, Kentaro Kai, Yasushi Kawano

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引用次数: 4

摘要

子宫内膜异位症是一种常见的雌激素依赖性良性肿瘤，影响3-10%的育龄妇女，其特征是子宫内膜组织异位生长，主要见于直肠阴道隔、卵巢和盆腔腹膜。迄今为止，越来越多的证据表明，各种表观遗传畸变，包括异常microRNAs (miRNAs)的表达，在子宫内膜异位症的发病机制中起着明确的作用。本文综述了近年来有关异常抑制mirna的研究进展，以及它们在子宫内膜异位症发病机制中的潜在作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Role of repressed microRNAs in endometriosis.

Endometriosis is a common, estrogen-dependent benign tumor that affect 3-10% women of reproductive age, and is characterized by the ectopic growth of endometrial tissue, which is found primarily in the rectovaginal septum, ovaries, and pelvic peritoneum. To date, accumulating evidence suggests that various epigenetic aberrations, including the expression of aberrant microRNAs (miRNAs), play definite roles in the pathogenesis of endometriosis. This review summarizes the recent findings on the aberrantly repressed miRNAs, as well as their potential roles regarding the pathogenesis of endometriosis.

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来源期刊

Medical Molecular Morphology 医学-病理学

CiteScore

2.90

自引率

5.60%

发文量

审稿时长

>12 weeks

期刊介绍： Medical Molecular Morphology is an international forum for researchers in both basic and clinical medicine to present and discuss new research on the structural mechanisms and the processes of health and disease at the molecular level. The structures of molecules, organelles, cells, tissues, and organs determine their normal function. Disease is thus best understood in terms of structural changes in these different levels of biological organization, especially in molecules and molecular interactions as well as the cellular localization of chemical components. Medical Molecular Morphology welcomes articles on basic or clinical research in the fields of cell biology, molecular biology, and medical, veterinary, and dental sciences using techniques for structural research such as electron microscopy, confocal laser scanning microscopy, enzyme histochemistry, immunohistochemistry, radioautography, X-ray microanalysis, and in situ hybridization. Manuscripts submitted for publication must contain a statement to the effect that all human studies have been reviewed by the appropriate ethics committee and have therefore been performed in accordance with the ethical standards laid down in an appropriate version of the 1964 Declaration of Helsinki. It should also be stated clearly in the text that all persons gave their informed consent prior to their inclusion in the study. Details that might disclose the identity of the subjects under study should be omitted.