尼日利亚西南部一个主要城市市场出售的草药消费与重金属和健康风险。

IF 2.4 Q1 Medicine
Johnson A Olusola, Oluwakemi B Akintan, Harrison A Erhenhi, Olagoke O Osanyinlusi
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引用次数: 7

摘要

背景:尽管草药作为药物来源发挥着重要作用,但人们对食用这些植物带来的风险表示担忧,尤其是在食用量超过允许水平的情况下。目的:本研究旨在评估尼日利亚Ado Ekiti城市市场食用草药的暴露水平、毒性和健康风险。方法:对Ado Eki城市市场出售的10种常用草药进行重金属分析。进行健康风险评估,以确定重金属的估计每日摄入量(EDI)、健康风险指数(HRI)、非致癌风险的目标危险系数和癌症风险估计(ECR),在儿童和成人中,铜(Cu)和镁(Mn)均高于所有研究植物物种的每日可耐受摄入量参考上限,这表明草药使用对这些草药产品的消费者构成短期到长期的健康风险。儿童的EDI明显低于成年人,这表明这些草药产品的成年消费者面临更高的风险。儿童Pb的HRI(Alstonia conensis、Terminalia avicennioides、Aframomum melegueta、Cymbopogon citratus和Napoleona vogelii)大于1;铜和锰的HRI也显示出异常高的浓度,这表明长期食用这些草药会对健康造成严重风险。儿童和成人的HRI依次为Mn>Cu>Ni>Pb>Cr;在任何一种草药植物中都没有检测到镉。儿童草药植物中Pb、Ni和Cr的ECR在10-6(低)到10-3(高)之间,而成人草药植物中铅、Ni和铬的ECR则在10-5(可接受)到10-2(不可接受)之间。对于儿童和成人来说,由于ECRs超过可接受的范围,都需要关注;食用这些草药植物会带来长期的癌症风险。结论:在儿童和成人中,本研究中某些草药的ECRs超过可接受范围对人类健康构成风险。食用这种草药植物会带来长期的癌症风险。竞争性利益:作者声明没有竞争性经济利益。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Heavy Metals and Health Risks Associated with Consumption of Herbal Plants Sold in a Major Urban Market in Southwest, Nigeria.

Heavy Metals and Health Risks Associated with Consumption of Herbal Plants Sold in a Major Urban Market in Southwest, Nigeria.

Heavy Metals and Health Risks Associated with Consumption of Herbal Plants Sold in a Major Urban Market in Southwest, Nigeria.

Heavy Metals and Health Risks Associated with Consumption of Herbal Plants Sold in a Major Urban Market in Southwest, Nigeria.

Background: Although herbal medicines play an important role as a source of medicine, concerns have been raised about the risks posed by consumption of these plants, especially if consumed above permissible levels.

Objectives: This study was undertaken to assess the level of exposure, toxicity and health risk associated with the consumption of herbal plants in Ado Ekiti urban market, Nigeria.

Methods: Ten commonly consumed herbal plants sold in Ado Ekiti urban market were subjected to heavy metal analysis. Health risk assessment was carried out to determine the estimated daily intake (EDI) of heavy metals, health risk index (HRI), target hazard quotient for non-carcinogenic risk and estimation of cancer risk (ECR).

Results: The EDIs for lead (Pb), nickel (Ni), chromium (Cr), copper (Cu) and magnesium (Mn) were above the upper tolerable daily intake reference for all studied plant species in both children and adults, an indication that herbal use poses a short-term to long-term health risk to consumers of these herbal products. The EDI for children was significantly lower compared to that of adults, indicating higher risks for adult consumers of these herbal products. The HRI in children for Pb (Alstonia congensis, Terminalia avicennioides, Aframomum melegueta, Cymbopogon citratus and Napoleona vogelii) were greater than 1; HRI in Cu and Mn also showed an unusually high concentration, an indication that long term exposure to the consumption of these herbal plants poses a serious health risk. The HRI in children and adults follows the order Mn > Cu > Ni > Pb > Cr; cadmium (Cd) was not detected in any of the herbal plants. The ECR for Pb, Ni and Cr present in the herbal plants for children ranged between 10-6 (low) to 10-3 (high), while the ECR for Pb, Ni and Cr for herbal plants for adults ranged between 10-5 (acceptable) to 10-2 (unacceptable). For both children and adults, there is a call for concern due to ECRs above the acceptable range; the consumption of these herbal plants poses a long-term cancer risk.

Conclusions: In both children and adults, ECRs for some of the herbal plants in the present study above the acceptable range present a risk to human health. The consumption of such herbal plants poses a long-term cancer risk.

Competing interests: The authors declare no competing financial interests.

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来源期刊
Journal of Health and Pollution
Journal of Health and Pollution Medicine-Public Health, Environmental and Occupational Health
自引率
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0
审稿时长
18 weeks
期刊介绍: The Journal of Health and Pollution (JH&P) was initiated with funding from the European Union and World Bank and continues to be a Platinum Open Access Journal. There are no publication or viewing charges. That is, there are no charges to readers or authors. Upon peer-review and acceptance, all articles are made available online. The high-ranking editorial board is comprised of active members who participate in JH&P submissions and editorial policies. The Journal of Health and Pollution welcomes manuscripts based on original research as well as findings from re-interpretation and examination of existing data. JH&P focuses on point source pollution, related health impacts, environmental control and remediation technology. JH&P also has an interest in ambient and indoor pollution. Pollutants of particular interest include heavy metals, pesticides, radionuclides, dioxins, polychlorinated biphenyls (PCBs), polycyclic aromatic hydrocarbons (PAHs), volatile organic compounds (VOCs), air particulates (PM10 and PM2.5), and other severe and persistent toxins. JH&P emphasizes work relating directly to low and middle-income countries, however relevant work relating to high-income countries will be considered on a case-by-case basis.
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