{"title":"一种新型Cd(II)化合物的发光特性及其在结核病治疗和临床护理中的应用价值。","authors":"Han-Xiao Tao, Jia-Li Jiang","doi":"10.1080/15685551.2021.1968113","DOIUrl":null,"url":null,"abstract":"<p><p>Through the reaction between HTrz and Cd(NO<sub>3</sub>)<sub>2</sub> · 4H<sub>2</sub>O, a new Cd(II) compound of [Cd(Trz) <sub>2</sub>] <sub>n</sub> (<b>1</b>, HTrz = 1,2,4-triazole) can be obtained, which has been studied with diffraction analysis by single crystal X-ray as well as powder X-ray diffraction. The structure of <b>1</b> can be stable up to 265°C, and the solid samples of <b>1</b> emit intense blue luminescence at room temperature. Along with the evaluation of tuberculosis treatment and clinical nursing, related mechanism was also studied here. Firstly, ELISA assay was conducted and the IL-10 and IL-18 released into the alveolar lavage fluid was determined. Apart from this, the real-time RT-PCR was used to reflect surviving gene's relative expression of <i>Mycobacterium tuberculosis</i> after compound treatment.</p>","PeriodicalId":11170,"journal":{"name":"Designed Monomers and Polymers","volume":null,"pages":null},"PeriodicalIF":1.8000,"publicationDate":"2021-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8381915/pdf/","citationCount":"0","resultStr":"{\"title\":\"Luminescent property and application values of a new Cd(II) compound in tuberculosis treatment and clinical nursing.\",\"authors\":\"Han-Xiao Tao, Jia-Li Jiang\",\"doi\":\"10.1080/15685551.2021.1968113\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Through the reaction between HTrz and Cd(NO<sub>3</sub>)<sub>2</sub> · 4H<sub>2</sub>O, a new Cd(II) compound of [Cd(Trz) <sub>2</sub>] <sub>n</sub> (<b>1</b>, HTrz = 1,2,4-triazole) can be obtained, which has been studied with diffraction analysis by single crystal X-ray as well as powder X-ray diffraction. The structure of <b>1</b> can be stable up to 265°C, and the solid samples of <b>1</b> emit intense blue luminescence at room temperature. Along with the evaluation of tuberculosis treatment and clinical nursing, related mechanism was also studied here. Firstly, ELISA assay was conducted and the IL-10 and IL-18 released into the alveolar lavage fluid was determined. Apart from this, the real-time RT-PCR was used to reflect surviving gene's relative expression of <i>Mycobacterium tuberculosis</i> after compound treatment.</p>\",\"PeriodicalId\":11170,\"journal\":{\"name\":\"Designed Monomers and Polymers\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.8000,\"publicationDate\":\"2021-08-19\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8381915/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Designed Monomers and Polymers\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://doi.org/10.1080/15685551.2021.1968113\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2021/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q3\",\"JCRName\":\"POLYMER SCIENCE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Designed Monomers and Polymers","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1080/15685551.2021.1968113","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2021/1/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"POLYMER SCIENCE","Score":null,"Total":0}
引用次数: 0
摘要
通过HTrz与Cd(NO3)2·4H2O的反应，可以得到新的Cd(II)化合物[Cd(Trz) 2] n (1,htrz = 1,2,4-三唑)，并通过单晶x射线衍射和粉末x射线衍射对其进行了研究。1的结构可以稳定到265℃，1的固体样品在室温下发出强烈的蓝色发光。同时结合肺结核治疗的评价和临床护理，对相关机制进行了研究。首先采用ELISA法测定大鼠肺泡灌洗液中IL-10和IL-18的释放量。此外，采用实时RT-PCR技术反映结核分枝杆菌复合治疗后存活基因的相对表达量。
Luminescent property and application values of a new Cd(II) compound in tuberculosis treatment and clinical nursing.
Through the reaction between HTrz and Cd(NO3)2 · 4H2O, a new Cd(II) compound of [Cd(Trz) 2] n (1, HTrz = 1,2,4-triazole) can be obtained, which has been studied with diffraction analysis by single crystal X-ray as well as powder X-ray diffraction. The structure of 1 can be stable up to 265°C, and the solid samples of 1 emit intense blue luminescence at room temperature. Along with the evaluation of tuberculosis treatment and clinical nursing, related mechanism was also studied here. Firstly, ELISA assay was conducted and the IL-10 and IL-18 released into the alveolar lavage fluid was determined. Apart from this, the real-time RT-PCR was used to reflect surviving gene's relative expression of Mycobacterium tuberculosis after compound treatment.
期刊介绍：
Designed Monomers and Polymers ( DMP) publishes prompt peer-reviewed papers and short topical reviews on all areas of macromolecular design and applications. Emphasis is placed on the preparations of new monomers, including characterization and applications. Experiments should be presented in sufficient detail (including specific observations, precautionary notes, use of new materials, techniques, and their possible problems) that they could be reproduced by any researcher wishing to repeat the work.
The journal also includes macromolecular design of polymeric materials (such as polymeric biomaterials, biomedical polymers, etc.) with medical applications.
DMP provides an interface between organic and polymer chemistries and aims to bridge the gap between monomer synthesis and the design of new polymers. Submssions are invited in the areas including, but not limited to:
-macromolecular science, initiators, macroinitiators for macromolecular design
-kinetics, mechanism and modelling aspects of polymerization
-new methods of synthesis of known monomers
-new monomers (must show evidence for polymerization, e.g. polycondensation, sequential combination, oxidative coupling, radiation, plasma polymerization)
-functional prepolymers of various architectures such as hyperbranched polymers, telechelic polymers, macromonomers, or dendrimers
-new polymeric materials with biomedical applications
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