不明原因不孕症和反复着床失败的子宫内膜因素。

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2021-11-01 Epub Date: 2021-08-23 DOI:10.1055/s-0041-1735199

Xavier Santamaria, Carlos Simón

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引用次数: 4

摘要

不明原因不孕症(UI)和复发性着床失败(RIF)是基于当前不孕症治疗模式中失败的妊娠尝试的诊断。这两种诊断都是在根据目前的诊断方法无法解释生育并且没有明确原因的情况下做出的;当检测结果不确定时诊断为UI，而在三次体外受精周期失败后诊断为RIF。在这两种情况下，通常在不了解不孕原因的情况下采取干预措施，这经常导致患者和护理人员感到沮丧。在这里，我们回顾证据来支持子宫内膜因子对这些诊断不明确的患者的影响，以及针对子宫内膜的可能治疗来改善这些患者的预后。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Endometrial Factor in Unexplained Infertility and Recurrent Implantation Failure.

Unexplained infertility (UI) and recurrent implantation failure (RIF) are diagnoses based on failed pregnancy attempts within current infertility treatment models. Both diagnoses are made when fertility is unexplained based on current diagnostic methods and has no clear cause; UI is diagnosed when testing is inconclusive, and RIF is diagnosed after three failed in vitro fertilization cycles. In both cases, interventions are often introduced without an understanding of the cause of the infertility, frequently leading to frustration for patients and caregivers. Here, we review evidence to support an influence of endometrial factor in patients given these poorly defined diagnoses and possible treatments targeting the endometrium to improve outcomes in these patients.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.