血清胆红素在结直肠癌手术切除患者中的预后价值。

IF 2.3 4区 医学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Zhangjun Jia, Zeyu Zhu, Ying Wang, Jing Ding, Zhenzhong Lin, Yanyan Zhang, Zhipeng Li
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引用次数: 8

摘要

目的:血清胆红素在抗氧化和抗癌过程中起重要作用。在多种癌症中,血清胆红素与癌症风险呈负相关已被广泛报道。本回顾性研究的目的是探讨血清胆红素对大肠癌手术切除患者预后的影响。方法:对330例大肠癌患者术前血清总胆红素、直接胆红素、间接胆红素进行测定。通过X-tile程序确定这三种生物标志物的最佳临界值。采用Kaplan-Meier曲线log-rank检验、单因素和多因素cox回归分析血清胆红素与预后的关系。此外,一些危险因素被用来形成一个nomogram来评估生存风险。结果:血清总胆红素、直接胆红素和间接胆红素的最佳临界值分别为19.5 μmol/L、5.0 μmol/L和8.1 μmol/L。总胆红素和直接胆红素升高与外科结直肠癌患者的总生存率显著相关。此外,还建立了包括总胆红素和直接胆红素在内的总生存预测图,用于预测外科结直肠癌患者的总生存。结论:这些发现提示术前总胆红素升高和直接胆红素升高可被视为结直肠癌患者总生存差的独立预后生物标志物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The prognostic value of serum bilirubin in colorectal cancer patients with surgical resection.

Purpose: Serum bilirubin plays an important role in antioxidant and anticancer processes. The inverse association between serum bilirubin and cancer risk have been widely reported in multiple cancers. The aim of this retrospective study was to investigate the prognostic impact of serum bilirubin in colorectal cancer patients undergoing surgical resection.

Methods: The value of serum bilirubin including total bilirubin, direct bilirubin, and indirect bilirubin were tested at pre-operatively in 330 colorectal cancer patients. The optimal cut-off values for these three biomarkers were determined by X-tile program. The relationship between serum bilirubin and outcomes were examined using Kaplan-Meier curves log-rank test, univariate and multivariate cox regression. Moreover, a number of risk factors were used to form a nomogram for evaluating risk of survival.

Results: The optimal cut-off points of serum total bilirubin, direct bilirubin, and indirect bilirubin were 19.5 μmol/L, 5.0 μmol/L and 8.1 μmol/L, respectively. Elevated total bilirubin and direct bilirubin were significantly associated with overall survival in surgical colorectal cancer patients. Additionally, predictive nomogram including total bilirubin and direct bilirubin for overall survival was established for predicting overall survival in surgical colorectal cancer patients.

Conclusions: These findings indicated that preoperative elevated total bilirubin and direct bilirubin could be considered as independent prognostic biomarkers for poor overall survival of colorectal cancer patients.

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来源期刊
International Journal of Biological Markers
International Journal of Biological Markers 医学-生物工程与应用微生物
CiteScore
4.10
自引率
0.00%
发文量
43
期刊介绍: IJBM is an international, online only, peer-reviewed Journal, which publishes original research and critical reviews primarily focused on cancer biomarkers. IJBM targets advanced topics regarding the application of biomarkers in oncology and is dedicated to solid tumors in adult subjects. The clinical scenarios of interests are screening and early diagnosis of cancer, prognostic assessment, prediction of the response to and monitoring of treatment.
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