水痘带状疱疹病毒的遗传、分子进化和重组。

3区医学 Q2 Medicine

Current topics in microbiology and immunology Pub Date : 2023-01-01 DOI:10.1007/82_2021_238

Daniel P Depledge, Judith Breuer

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引用次数: 2

摘要

本章首先详细介绍VZV基因组的结构、组织和编码内容，为预测病毒的分子进化提供基础。我们随后描述了分子分析方法的演变，从限制性片段长度多态性到单核苷酸多态性分析，再到现代高通量测序方法。我们描述了这些方法的应用如何导致我们目前的VZV系统地理学模型，包括地理分支的数量和结构以及重组在重塑这些分支中的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Varicella-Zoster Virus-Genetics, Molecular Evolution and Recombination.

This chapter first details the structure, organization and coding content of the VZV genome to provide a foundation on which the molecular evolution of the virus can be projected. We subsequently describe the evolution of molecular profiling approaches from restriction fragment length polymorphisms to single nucleotide polymorphism profiling to modern day high-throughput sequencing approaches. We describe how the application of these methodologies led to our current model of VZV phylogeograpy including the number and structure of geographic clades and the role of recombination in reshaping these.

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来源期刊

Current topics in microbiology and immunology 医学-免疫学

CiteScore

5.60

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： The review series Current Topics in Microbiology and Immunology provides a synthesis of the latest research findings in the areas of molecular immunology, bacteriology and virology. Each timely volume contains a wealth of information on the featured subject. This review series is designed to provide access to up-to-date, often previously unpublished information.