Brechje de Gier, Stijn Andeweg, Rosa Joosten, Ronald Ter Schegget, Naomi Smorenburg, Jan van de Kassteele, Susan Jm Hahné, Susan van den Hof, Hester E de Melker, Mirjam J Knol
{"title":"2021年2月至5月荷兰对确诊病例的家庭和其他密切接触者中SARS-CoV-2传播和感染的疫苗有效性","authors":"Brechje de Gier, Stijn Andeweg, Rosa Joosten, Ronald Ter Schegget, Naomi Smorenburg, Jan van de Kassteele, Susan Jm Hahné, Susan van den Hof, Hester E de Melker, Mirjam J Knol","doi":"10.2807/1560-7917.ES.2021.26.31.2100640","DOIUrl":null,"url":null,"abstract":"<p><p>Several studies report high effectiveness of COVID-19 vaccines against SARS-CoV-2 infection and severe disease, however an important knowledge gap is the vaccine effectiveness against transmission (VET). We present estimates of the VET to household and other close contacts in the Netherlands, from February to May 2021, using contact monitoring data. The secondary attack rate among household contacts was lower for fully vaccinated than unvaccinated index cases (11% vs 31%), with an adjusted VET of 71% (95% confidence interval: 63-77).</p>","PeriodicalId":520613,"journal":{"name":"Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8343550/pdf/","citationCount":"61","resultStr":"{\"title\":\"Vaccine effectiveness against SARS-CoV-2 transmission and infections among household and other close contacts of confirmed cases, the Netherlands, February to May 2021.\",\"authors\":\"Brechje de Gier, Stijn Andeweg, Rosa Joosten, Ronald Ter Schegget, Naomi Smorenburg, Jan van de Kassteele, Susan Jm Hahné, Susan van den Hof, Hester E de Melker, Mirjam J Knol\",\"doi\":\"10.2807/1560-7917.ES.2021.26.31.2100640\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Several studies report high effectiveness of COVID-19 vaccines against SARS-CoV-2 infection and severe disease, however an important knowledge gap is the vaccine effectiveness against transmission (VET). We present estimates of the VET to household and other close contacts in the Netherlands, from February to May 2021, using contact monitoring data. The secondary attack rate among household contacts was lower for fully vaccinated than unvaccinated index cases (11% vs 31%), with an adjusted VET of 71% (95% confidence interval: 63-77).</p>\",\"PeriodicalId\":520613,\"journal\":{\"name\":\"Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2021-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8343550/pdf/\",\"citationCount\":\"61\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.2807/1560-7917.ES.2021.26.31.2100640\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2807/1560-7917.ES.2021.26.31.2100640","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Vaccine effectiveness against SARS-CoV-2 transmission and infections among household and other close contacts of confirmed cases, the Netherlands, February to May 2021.
Several studies report high effectiveness of COVID-19 vaccines against SARS-CoV-2 infection and severe disease, however an important knowledge gap is the vaccine effectiveness against transmission (VET). We present estimates of the VET to household and other close contacts in the Netherlands, from February to May 2021, using contact monitoring data. The secondary attack rate among household contacts was lower for fully vaccinated than unvaccinated index cases (11% vs 31%), with an adjusted VET of 71% (95% confidence interval: 63-77).