白介素-32基因多态性与子痫前期易感性的关系

IF 1.5 4区医学 Q3 OBSTETRICS & GYNECOLOGY

Hypertension in Pregnancy Pub Date : 2021-08-01 Epub Date: 2021-08-04 DOI:10.1080/10641955.2021.1958836

Fatemeh Mazlum, Behrouz Gharesi-Fard, Hossein Hadinedoushan, Yousef Bakhshizadeh Ghashti

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引用次数: 6

摘要

目的:探讨IL-32基因多态性、血清IL-32水平与子痫前期(PE)易感性的关系。方法:采用PCR-RFLP法检测IL-32 rs9927163和rs4786370基因多态性频率。ELISA法测定血清IL-32水平。结果:在rs4786370 C/T snp中，CT、TT基因型和T等位基因的频率在PE患者中较高。PE患者血清IL-32水平明显升高。结论:IL32 rs4786370等位基因和基因型的变异以及血清IL-32水平的升高可视为PE的危险因素。

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Association between interleukin-32 gene polymorphism and susceptibility to preeclampsia.

Objective: To determine association between IL-32 gene polymorphism, and serum levels of IL-32 and susceptibility to preeclampsia (PE).

Methods: The frequency of IL-32 rs9927163 and rs4786370 polymorphisms was determined by PCR-RFLP. Also ELISA was used to determine the levels of serum IL-32.

Results: Regarding rs4786370 C/T SNPs, the frequencies of CT, TT genotypes, and T allele were shown to be higher in the PE patients. IL-32 serum level significantly increased in the PE patients.

Conclusion: Variety of allele and genotype IL32 rs4786370 as well as a rise in serum level of IL-32 can be regarded as a risk factor for PE.

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来源期刊

Hypertension in Pregnancy 医学-妇产科学

CiteScore

3.40

自引率

0.00%

发文量

审稿时长

6 months

期刊介绍： Hypertension in Pregnancy is a refereed journal in the English language which publishes data pertaining to human and animal hypertension during gestation. Contributions concerning physiology of circulatory control, pathophysiology, methodology, therapy or any other material relevant to the relationship between elevated blood pressure and pregnancy are acceptable. Published material includes original articles, clinical trials, solicited and unsolicited reviews, editorials, letters, and other material deemed pertinent by the editors.