控制人类感染钩虫寄生虫 Necator americanus 以加速疫苗开发：人类钩虫疫苗接种/挑战模型 (HVCM)。

3区医学 Q2 Medicine

Current topics in microbiology and immunology Pub Date : 2024-01-01 DOI:10.1007/82_2021_237

David I Pritchard, David Diemert, Maria Elena Bottazzi, John M Hawdon, Rodrigo Correa-Oliveira, Jeffrey M Bethony

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引用次数: 0

摘要

在本章中，我们将介绍在非流行区和流行区建立人类钩虫控制感染 (CHHI) 模型的科学、技术、临床和监管方面的情况，以促进加速疫苗开发的途径。在建立受控人类钩虫感染（CHHI）平台方面取得的成功使人类钩虫疫苗计划（HHVI）能够在巴西钩虫流行地区建立人类钩虫疫苗接种/挑战模型（HVCM），从而加快进度。HVCM 将允许快速、稳健地确定成人的临床疗效，从而及早选出最有效的人类钩体病疫苗候选疫苗，进入后期的关键儿科临床试验，并减少疗效评估所需的总体参与人数（Diemert 等，2018 年）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Controlled Infection of Humans with the Hookworm Parasite Necator americanus to Accelerate Vaccine Development : The Human Hookworm Vaccination/Challenge Model (HVCM).

In this chapter, we describe the scientific, technical, clinical and regulatory aspects of establishing a controlled human hookworm infection (CHHI) model in non-endemic and endemic geographical regions, to facilitate a pathway towards accelerated vaccine development. The success achieved in establishing the CHHI platform specifically allows the Human Hookworm Vaccine Initiative (HHVI) to accelerate its progress by establishing a human hookworm vaccination/challenge model (HVCM) in a hookworm endemic area of Brazil. The HVCM will permit the rapid and robust determination of clinical efficacy in adults, allowing for early selection of the most efficacious human hookworm vaccine (HHV) candidate(s) to advance into later-stage pivotal paediatric clinical trials and reduce the overall number of participants required to assess efficacy (Diemert et al. 2018).

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来源期刊

Current topics in microbiology and immunology 医学-免疫学

CiteScore

5.60

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： The review series Current Topics in Microbiology and Immunology provides a synthesis of the latest research findings in the areas of molecular immunology, bacteriology and virology. Each timely volume contains a wealth of information on the featured subject. This review series is designed to provide access to up-to-date, often previously unpublished information.