不同年龄小鼠外周器官中FAM83D的动态表达

IF 1 4区生物学 Q4 DEVELOPMENTAL BIOLOGY

Gene Expression Patterns Pub Date : 2021-09-01 DOI:10.1016/j.gep.2021.119199

Qixian Li, Kaicheng Zhou, Demin Du, Yali Chen, Dekang Liu, Xiaowei Guan

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引用次数: 0

摘要

序列相似度为83的家族成员(FAM83D)在细胞分裂和肿瘤进展过程中发挥重要作用。然而，FAM83D在组织发育中的作用尚未得到很好的探讨。在这里，我们评估了不同年龄小鼠器官中FAM83D和其他可能相关基因的转录水平以及FAM83D启动子的甲基化水平。我们的研究结果揭示了FAM83D在小鼠睾丸、肝脏、肺和小肠中的表达趋势及其与CYCLINB1和KI67的关系。最后，我们发现启动子甲基化状态对小鼠发育过程中FAM83D的表达没有影响。

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Dynamic expression of FAM83D in peripheral organs at different ages in mice

The family with sequence similarity 83 member (FAM83D) plays important role in the process of cell division as well as tumour progression. However, the role of FAM83D in tissue development was not well explored. Here, we assessed transcriptional levels of FAM83D and other possibly related genes in organs of mice at different ages and methylation level of FAM83D promoter. Our results indicate the trend of FAM83D expression in mouse testis, liver, lung and small intestine, and its relationship to CYCLINB1 and KI67. Finally, we found no effect of promoter methylation status on FAM83D expression during mice development.

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来源期刊

Gene Expression Patterns 生物-发育生物学

CiteScore

2.30

自引率

0.00%

发文量

审稿时长

35 days

期刊介绍： Gene Expression Patterns is devoted to the rapid publication of high quality studies of gene expression in development. Studies using cell culture are also suitable if clearly relevant to development, e.g., analysis of key regulatory genes or of gene sets in the maintenance or differentiation of stem cells. Key areas of interest include: -In-situ studies such as expression patterns of important or interesting genes at all levels, including transcription and protein expression -Temporal studies of large gene sets during development -Transgenic studies to study cell lineage in tissue formation