牛皮癣和心脏代谢疾病:炎症对血管健康的影响。

IF 5.2 Q1 DERMATOLOGY
Psoriasis (Auckland, N.Z.) Pub Date : 2021-07-21 eCollection Date: 2021-01-01 DOI:10.2147/PTT.S320016
Meron Teklu, Philip M Parel, Nehal N Mehta
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引用次数: 7

摘要

牛皮癣是一种常见的慢性炎症,与心血管疾病的高风险相关。银屑病使代谢综合征及其组成部分的风险呈剂量依赖性增加。代谢综合征及其成分与银屑病患者的冠状动脉粥样硬化和普通人群的心血管事件有关。在这篇综述中,我们讨论了炎症和牛皮癣在心血管代谢疾病中的作用,重点是代谢综合征及其组成部分。我们强调牛皮癣与重要的心血管危险因素包括肥胖,血脂异常,胰岛素抵抗和高血压之间的关系。此外,我们简要介绍了有关抗炎疗法及其对代谢综合征组成部分的影响以及直接量化冠状动脉粥样硬化负担的文献。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Psoriasis and Cardiometabolic Diseases: The Impact of Inflammation on Vascular Health.

Psoriasis and Cardiometabolic Diseases: The Impact of Inflammation on Vascular Health.

Psoriasis and Cardiometabolic Diseases: The Impact of Inflammation on Vascular Health.

Psoriasis and Cardiometabolic Diseases: The Impact of Inflammation on Vascular Health.

Psoriasis is a common chronic inflammatory condition associated with a higher risk of cardiovascular disease. Psoriasis confers a dose-dependent increase in risk for the metabolic syndrome and its components. The metabolic syndrome and its components have been associated with higher coronary atherosclerosis in psoriasis and cardiovascular events in the general population. In this review, we discuss the role of inflammation and psoriasis in cardiometabolic diseases with a focus on the metabolic syndrome and its components. We highlight the relationship between psoriasis and important cardiovascular risk factors encompassed by obesity, dyslipidemia, insulin resistance and hypertension. Furthermore, we briefly highlight literature on anti-inflammatory therapies and their impact on the components of the metabolic syndrome as well as directly quantified coronary atherosclerosis burden.

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