铁蛋白、维生素B12和维生素D在纤维肌痛综合征的发病机制中起作用吗?

IF 1.6 Q2 MEDICINE, GENERAL & INTERNAL
Romanian Journal of Internal Medicine Pub Date : 2021-11-20 Print Date: 2021-12-01 DOI:10.2478/rjim-2021-0022
Adem Kucuk, Rabia Aydogan Baykara, Ayca Tuzcu, Ahmet Omma, Medine Cumhur Cure, Erkan Cure, Gunseli Karaca Acet, Erdal Dogan
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引用次数: 1

摘要

介绍。纤维肌痛综合征(FS)包括全身疼痛、睡眠障碍和疲劳。维生素B12 (VB)、维生素D (VD)和铁缺乏也会导致类似的症状。首先,本研究旨在评估FS患者的VB、VD和铁蛋白水平。其次,研究这些参数与FS严重程度之间是否存在关系。材料和方法。研究对象为58名女性FS患者和58名健康女性作为对照组。患者完成纤维肌痛影响问卷(FIQ)、视觉模拟量表(VAS)、疲劳问卷、匹兹堡睡眠质量量表和SF-36量表。本研究检测了患者和对照组的VD、VB和铁蛋白水平。结果。VB (240.0 [110.0-394.0] vs 291.0 [210.0-609.0] pg/ml, p。FS患者的VB、VD和铁蛋白水平可能与压痛点数量有关。铁和维生素b水平可能在FS发病过程中起重要作用。然而,VD水平可能不是FS发病的危险因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Could ferritin, vitamin B12, and vitamin D play a role in the etiopathogenesis of fibromyalgia syndrome?

Introduction. Fibromyalgia syndrome (FS) comprises general body pain, sleep disturbances, and fatigue. Vitamin B12 (VB), vitamin D (VD), and iron deficiencies lead to similar complaints. First, this study aimed to evaluate the VB, VD, and ferritin levels of patients with FS. Second, it aimed to investigate whether there was a relationship between these parameters and FS severity. Material and methods. The study included 58 female patients with FS and 58 healthy females as a control group. The patients completed the Fibromyalgia Impact Questionnaire (FIQ), Visual Analog Scale (VAS), fatigue questionnaire, Pittsburgh sleep quality scale, and the Short Form-36 (SF-36). This study examined the VD, VB, and ferritin levels of the patient and control groups. Results. The VB (240.0 [110.0-394.0] vs 291.0 [210.0-609.0] pg/ml, p<0.001), VD (12.5 [3.0-45.0] vs 20.0 [5.0-54.0] ng/ml, p=0.013), and ferritin levels (21.2 [4.0-86.0] vs 32.0 [7.1-120.0], ng/ml, p=0.009) of the FS patients were determined to be significantly lower than those of the control group. A negative correlation was determined between the number of tender points and VB, VD, and ferritin levels. In the regression analysis, we found low ferritin levels (odds ratio [OR] 1.036, 95% confidence interval [CI] 1.015-1.058, p<0.001) and VB (OR 1.010, CI 1.002-1.018, p=0.010) to be an independent risk factor for FS. Conclusions. There may be a relationship between VB, VD, and ferritin levels and the number of tender points in patients with FS. Levels of iron and VB may play a vital role in FS etiopathogenesis. However, VD levels may not be a risk factor for FS etiopathogenesis.

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来源期刊
Romanian Journal of Internal Medicine
Romanian Journal of Internal Medicine MEDICINE, GENERAL & INTERNAL-
CiteScore
3.20
自引率
5.30%
发文量
35
审稿时长
15 weeks
期刊介绍: Romanian Journal of Physics is a journal publishing physics contributions on the following themes: •Theoretical Physics & Applied Mathematics •Nuclear Physics •Solid State Physics & Materials Science •Statistical Physics & Quantum Mechanics •Optics •Spectroscopy •Plasma & Lasers •Nuclear & Elementary Particles Physics •Atomic and Molecular Physics •Astrophysics •Atmosphere and Earth Science •Environment Protection
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