输尿管透明细胞腺癌与肾透明细胞癌相似。

Case Reports in Urology Pub Date : 2021-05-28 eCollection Date: 2021-01-01 DOI:10.1155/2021/5599014
Kazuhiro Watanabe, Go Hasegawa, Yohei Ikeda, Noboru Hara, Tsutomu Nishiyama
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引用次数: 0

摘要

一名70岁妇女因肉眼血尿转诊至我院,诊断为右侧浸润性输尿管癌及膀胱尿路上皮原位癌。膀胱内卡介苗治疗与卡铂和吉西他滨新辅助化疗同时进行。随后行腹腔镜右肾输尿管切除术。尿路上皮原位癌持续存在;但多数为透明细胞癌。透明细胞癌病变的细胞质清晰,细胞核圆形,可见核仁呈岛状排列,透明细胞肾细胞癌可见核仁。未见透明细胞腺癌与尿路上皮癌之间的过渡性病变。透明细胞癌病变GATA3阴性,HNF4α阳性;而尿路上皮癌病变GATA3阳性,HNF4α阴性。透明细胞癌诊断为与透明细胞肾细胞癌相似的透明细胞腺癌。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Clear Cell Adenocarcinoma of the Ureter Similar to Clear Cell Renal Cell Carcinoma Histology.

Clear Cell Adenocarcinoma of the Ureter Similar to Clear Cell Renal Cell Carcinoma Histology.

Clear Cell Adenocarcinoma of the Ureter Similar to Clear Cell Renal Cell Carcinoma Histology.

A 70-year-old woman was referred to our hospital with gross hematuria and diagnosed with right invasive ureteral cancer and bladder urothelial carcinoma in situ. Intravesical BCG therapy and neoadjuvant chemotherapy with carboplatin and gemcitabine were performed at the same time. Subsequently, laparoscopic right nephroureterectomy was performed. Urothelial carcinoma in situ persisted; however, most of the tumor was clear cell carcinoma. The clear cell carcinoma lesion had clear cytoplasm with round nuclei and visible nucleoli in an insular arrangement as is the case with clear cell renal cell carcinoma. No transitional lesion between clear cell adenocarcinoma and urothelial carcinoma was presented. The clear cell carcinoma lesion was GATA3 negative and HNF4α positive; however, the urothelial cancer lesion was GATA3 positive and HNF4α negative. Clear cell carcinoma was diagnosed as clear cell adenocarcinoma similar to clear cell renal cell carcinoma histology.

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