同种异体移植治疗同卵双胞胎的一致性急性髓母细胞白血病。同种异体移植来自一个年轻的hla相同的兄弟姐妹。

International Journal of Hematologic Oncology Pub Date : 2020-11-16 DOI:10.2217/ijh-2020-0017

Yajaira Valentine Jimenez-Antolinez, Elias Eugenio Gonzalez-Lopez, Ileana Yazmín Velasco Ruiz, Marcela Cantu-Moreno, David Gomez-Almaguer, Oscar Gonzalez-Llano

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引用次数: 1

摘要

一致性白血病是发生在一对同卵双胞胎中;相似的遗传背景提示子宫内单克隆起源。我们报告了一对患有一致性急性髓性白血病的同卵婴儿，他们接受了外周血造血干细胞移植(HSCT)，来自一个年轻的人类白细胞抗原相同的兄弟姐妹供体，使用仅在一次分离过程中收集的分块移植物。双胞胎A在+456时复发，并从父亲那里接受了第二次单倍同卵HSCT，双胞胎B自第一次HSCT以来已完全缓解。两名儿童分别在+900(第二次移植后)和+1488时完全缓解，最小残留疾病呈阴性。

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Concordant acute myeloblastic leukemia in identical twins treated with allogeneic transplantation from a younger HLA-identical sibling following a single apheresis procedure.

A concordant leukemia is that which occurs in a pair of monozygotic twins; a similar genetic background suggests an in utero monoclonal origin. We present the case of a pair of monozygotic infants with concordant acute myeloid leukemia who underwent a peripheral blood hematopoietic stem-cell transplant (HSCT) from a single, younger human leukocyte antigen-identical sibling donor, using a fractioned graft collected during only one apheresis procedure. Twin A relapsed at +456 and received a second haploidentical HSCT from his father, twin B has been in complete remission since the first HSCT. Both children are in complete remission and with negative minimal residual disease at +900 (after second transplant) and +1488, respectively.

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来源期刊

International Journal of Hematologic Oncology

自引率

0.00%

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审稿时长

13 weeks

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