与鼻咽癌侵袭转移相关的微小rna研究进展。

IF 2.4 4区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Current molecular pharmacology Pub Date : 2022-01-01 DOI:10.2174/1874467214666210614150720

ShanShan Zhang, BaiQi Wang, LuLu Zheng, ZhuQiong Fu, YiTing Fu, WeiGuo Huang, AiLan Cheng

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引用次数: 0

摘要

鼻咽癌(NPC)是一种独特的发生于鼻咽粘膜的上皮性恶性肿瘤，多数病例伴有潜伏性eb病毒感染。越来越多的证据提供了对可能驱动鼻咽肿瘤发展和进展的遗传和分子畸变的见解。我们回顾了最近对可能与鼻咽癌转移有关的microRNAs (miRNAs)的分析，包括eb病毒编码的miRNAs (ebv编码的miRNAs)和失调的细胞miRNAs。本文总结的研究成果极大地扩展了我们对涉及mirna的鼻咽癌分子生物学的认识，并可能为临床诊断提供新的生物学靶点，揭示mirna治疗的潜力。然而，还有很多事情有待发现。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Advances in Research on microRNAs Related to the Invasion and Metastasis of Nasopharyngeal Carcinoma.

Nasopharyngeal Carcinoma (NPC), which is associated with latent Epstein-Barr virus infection in most cases, is a unique epithelial malignancy arising from the nasopharyngeal mucosal lining. Accumulating evidence is providing insights into the genetic and molecular aberrations that likely drive nasopharyngeal tumor development and progression. We review recent analyses of microRNAs (miRNAs), including Epstein-Barr virus-encoded miRNAs (EBV-encoded miRNAs) and dysregulated cellular miRNAs, that may be related to the metastasis of nasopharyngeal carcinoma. The studies summarized herein have greatly expanded our knowledge of the molecular biology of NPC involving miRNAs, and they may provide new biological targets for clinical diagnosis and reveal the potential of microRNA therapeutics. However, much remains to be uncovered.

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来源期刊

Current molecular pharmacology Pharmacology, Toxicology and Pharmaceutics-Drug Discovery

CiteScore

4.90

自引率

3.70%

发文量

112

期刊介绍： Current Molecular Pharmacology aims to publish the latest developments in cellular and molecular pharmacology with a major emphasis on the mechanism of action of novel drugs under development, innovative pharmacological technologies, cell signaling, transduction pathway analysis, genomics, proteomics, and metabonomics applications to drug action. An additional focus will be the way in which normal biological function is illuminated by knowledge of the action of drugs at the cellular and molecular level. The journal publishes full-length/mini reviews, original research articles and thematic issues on molecular pharmacology. Current Molecular Pharmacology is an essential journal for every scientist who is involved in drug design and discovery, target identification, target validation, preclinical and clinical development of drugs therapeutically useful in human disease.