甲状腺激素在女性颈动脉壁重塑中的作用。

IF 1.6 Q2 MEDICINE, GENERAL & INTERNAL
Romanian Journal of Internal Medicine Pub Date : 2022-03-17 Print Date: 2022-03-01 DOI:10.2478/rjim-2021-0028
Maida Seferovic Saric, Miljenka-Jelena Jurasic, Hrvoje Budincevic, Milan Milosevic, Bojana Kranjcec, Sanja Kovacic, Jana Leskovar, Vida Demarin
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引用次数: 1

摘要

简介:甲状腺激素影响心血管系统,但其影响动脉粥样硬化发展的确切机制尚不完全清楚。亚临床甲状腺功能减退、血脂异常与颈动脉粥样硬化之间的关系已被广泛研究,但研究结果存在争议。本研究的目的是确定女性亚临床甲状腺功能减退症(SHypo)患者是否比甲状腺功能正常的患者颈动脉内膜-中膜厚度(IMT)增加,并研究SHypo与颈动脉粥样硬化和血脂异常的关系。方法:将100名年龄在30 ~ 70岁的女性分为两组:SHypo组(有亚临床甲状腺功能减退症状者)和对照组(甲状腺功能正常者)。通过B超确定颈动脉IMT厚度,并分析其与血清fT4、TSH、CRP浓度和血脂(包括小密度LDL)的相关性。结果:与对照组相比,SHypo患者在右颈动脉所有三个测量段(p p = 0.001)的颈动脉IMT (IMT≥75百分位)均显著增加,斑块出现频率显著增加(25% vs. 9%;P = 0.05)。较高的TSH值与较高的IMT值之间存在显著正相关。增加的年龄、LDL胆固醇和TSH预测颈动脉IMT增厚。结论:由于甲状腺功能障碍对颈动脉粥样硬化的发展有影响,对早期出现亚临床症状的甲状腺功能障碍患者进行筛查是很重要的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The role of thyroid hormones in carotid arterial wall remodeling in women.

Introduction: Thyroid hormones affect the cardiovascular system, but the precise mechanisms of their effects on the development of atherosclerosis are not entirely clear. The relationship between subclinical hypothyroidism, dyslipidemia and carotid atherosclerosis has been widely investigated, but the findings were controversial. The aim of the present study was to determine whether female subjects with subclinical hypothyroidism (SHypo) have increased carotid intima-media thickness (IMT) compared with euthyroid subjects, as well as to examine the association of SHypo, carotid atherosclerosis and dyslipidemia.Methods: This research included 100 women aged 30 to 70 years who were divided into two groups: the SHypo group including subjects with signs of subclinical hypothyroidism and the control group of euthyroid subjects. Carotid IMT thickness using B mode ultrasound was determined and its correlation with serum concentrations of fT4, TSH, CRP, and lipid profile including small dense LDL (sdLDL) was analysed.Results: Subjects with SHypo had significantly increased carotid IMT (IMT ≥ 75th centile) in all three measured segments of the right (p <0.001) and the left (p = 0.001) carotid artery compared to the control group, with a significantly more frequent appearance of plaque (25% vs. 9%; p = 0.05). Significant positive correlations were found between higher TSH and higher IMT values. Increased age, LDL cholesterol, and TSH predicted thickening of the carotid artery IMT.Conclusions: It is important to screen people showing early, subclinical signs of thyroid gland dysfunction due to its impact on carotid atherosclerosis development.

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来源期刊
Romanian Journal of Internal Medicine
Romanian Journal of Internal Medicine MEDICINE, GENERAL & INTERNAL-
CiteScore
3.20
自引率
5.30%
发文量
35
审稿时长
15 weeks
期刊介绍: Romanian Journal of Physics is a journal publishing physics contributions on the following themes: •Theoretical Physics & Applied Mathematics •Nuclear Physics •Solid State Physics & Materials Science •Statistical Physics & Quantum Mechanics •Optics •Spectroscopy •Plasma & Lasers •Nuclear & Elementary Particles Physics •Atomic and Molecular Physics •Astrophysics •Atmosphere and Earth Science •Environment Protection
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