癌症中的钾和氯离子通道:癌症治疗的新范式。

2区医学 Q1 Biochemistry, Genetics and Molecular Biology

Reviews of Physiology Biochemistry and Pharmacology Pub Date : 2022-01-01 DOI:10.1007/112_2021_62

Umberto Banderali, Luigi Leanza, Najmeh Eskandari, Saverio Gentile

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引用次数: 3

摘要

癌症是由基因组水平的特定变化引起的一系列疾病，这些变化无限期地支持细胞增殖。传统上，已知离子通道通过控制离子梯度来控制各种细胞过程，包括电信号的产生和传递、分泌和收缩。然而，最近的研究揭示了癌症生物学中离子通道的重要事实。在这篇综述中，我们讨论了将钾或氯离子通道活性与控制癌细胞增殖的生化途径联系起来的机制以及靶向离子通道作为抗癌治疗选择的潜在优势。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Potassium and Chloride Ion Channels in Cancer: A Novel Paradigm for Cancer Therapeutics.

Cancer is a collection of diseases caused by specific changes at the genomic level that support cell proliferation indefinitely. Traditionally, ion channels are known to control a variety of cellular processes including electrical signal generation and transmission, secretion, and contraction by controlling ionic gradients. However, recent studies had brought to light important facts on ion channels in cancer biology.In this review we discuss the mechanism linking potassium or chloride ion channel activity to biochemical pathways controlling proliferation in cancer cells and the potential advantages of targeting ion channels as an anticancer therapeutic option.

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来源期刊

Reviews of Physiology Biochemistry and Pharmacology 医学-生化与分子生物学

CiteScore

11.40

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： The highly successful Reviews of Physiology, Biochemistry and Pharmacology continue to offer high-quality, in-depth reviews covering the full range of modern physiology, biochemistry and pharmacology. Leading researchers are specially invited to provide a complete understanding of the key topics in these archetypal multidisciplinary fields. In a form immediately useful to scientists, this periodical aims to filter, highlight and review the latest developments in these rapidly advancing fields.