非情感性精神病中洞察力的神经影像学相关性:系统回顾和荟萃分析

IF 5.2 3区 医学 Q1 PSYCHIATRY
Pau Soldevila-Matías , Georgios Schoretsanitis , Diana Tordesillas-Gutierrez , Manuel J. Cuesta , Renato de Filippis , Rosa Ayesa-Arriola , Carlos González-Vivas , Esther Setién-Suero , Norma Verdolini , Julio Sanjuán , Joaquim Radua , Benedicto Crespo-Facorro
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引用次数: 2

摘要

目的:非情感性精神病中洞察力受损的神经学相关性尚不清楚。本研究旨在回顾和荟萃分析评估非情感性精神病中洞察力受损的灰质体积相关性的研究。方法:本研究包括对23项研究的系统综述,以及对11项全脑研究的SDM-PSI的荟萃分析,并报告了研究非情感性精神病洞察力评估的灰质体积相关性的研究的图或相关性峰值,PubMed和OVID数据集独立审查了报告非情感性精神病洞察力神经影像学相关性的文章。质量评估是根据先前影像学研究ABC质量评估测试的方法方法来实现的,基于两个主要标准:统计能力和洞察力的多维评估。研究人员利用灰质体积和洞察力之间的相关峰值来重建大脑相关图。结果通过数据库检索,共鉴定出418条记录。在这些记录中,包括23个使用不同洞察力量表的磁共振成像(MRI)研究。11项研究的证据质量为高,9项为中等,3项为低。洞察力下降的患者表现为额叶、颞叶(特别是颞上回)、楔前叶、扣带回、岛叶和枕叶皮层灰质体积减少。荟萃分析表明,右脑岛灰质体积与洞察力呈正相关(即灰质越小,洞察力越低)。结论非情感性精神病患者的洞察力受损可能涉及多个脑区。所采用的方法,如应用的洞察力量表,可能导致了研究结果中的相当大的差异。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Neuroimaging correlates of insight in non-affective psychosis: A systematic review and meta-analysis

Objective

Neurological correlates of impaired insight in non-affective psychosis remain unclear. This study aimed to review and meta-analyze the studies assessing the grey matter volumetric correlates of impaired insight in non-affective psychosis.

Methods

This study consisted of a systematic review of 23 studies, and a meta-analysis with SDM-PSI of the 11 studies that were whole-brain and reported maps or peaks of correlation of studies investigating the grey matter volumetric correlates of insight assessments of non-affective psychosis, PubMed and OVID datasets were independently reviewed for articles reporting neuroimaging correlates of insight in non-affective psychosis. Quality assessment was realized following previous methodological approaches for the ABC quality assessment test of imaging studies, based on two main criteria: the statistical power and the multidimensional assessment of insight. Study peaks of correlation between grey matter volume and insight were used to recreate brain correlation maps.

Results

A total of 418 records were identified through database searching. Of these records, twenty-three magnetic resonance imaging (MRI) studies that used different insight scales were included. The quality of the evidence was high in 11 studies, moderate in nine, and low in three. Patients with reduced insight showed decreases in the frontal, temporal (specifically in superior temporal gyrus), precuneus, cingulate, insula, and occipital lobes cortical grey matter volume. The meta-analysis indicated a positive correlation between grey matter volume and insight in the right insula (i.e., the smaller the grey matter, the lower the insight).

Conclusion

Several brain areas might be involved in impaired insight in patients with non-affective psychoses. The methodologies employed, such as the applied insight scales, may have contributed to the considerable discrepancies in the findings.

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来源期刊
自引率
3.30%
发文量
58
期刊介绍: The Spanish Journal of Psychiatry and Mental Health (SJPMH), incorporated into ISSN 1888-9891, is the official scientific publication of the Spanish Society of Psychiatry and Mental Health. The journal focuses on studying mental illnesses, their pathological processes, and their psychosocial consequences, and aims to disseminate scientific advances in all areas related to mental health and illness. SJPMH accepts unpublished works on psychiatry and mental health, including their medical and social implications. The journal provides space for research in the biological, clinical, and psychosocial fields. Manuscripts undergo peer-review by external reviewers before being accepted for publication. SJPMH is indexed in Index Medicus/Medline, IBECS, Social Sciences Citation Index Journal Citation Reports/Social Sciences Edition, and Current Contents/Social and Behavioral Sciences.
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