去泛素化酶对神经干细胞生物学行为的影响

IF 2.7 4区医学 Q2 DEVELOPMENTAL BIOLOGY

Developmental Neurobiology Pub Date : 2021-07-09 DOI:10.1002/dneu.22844

Qiqi Zhao, Yixin Li, Xixun Du, Xi Chen, Qian Jiao, Hong Jiang

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引用次数: 0

摘要

由于神经干细胞(NSCs)的增殖和分化，哺乳动物大脑的不同区域在整个生命过程中都会产生新的神经元。泛素是细胞蛋白的翻译后修饰，是调节神经发生的重要因素。去泛素化是一个生化过程，介导从泛素缀合底物中去除泛素部分。近年来越来越多的研究表明，反泛素化过程的去泛素化酶(deubiquitylases, DUBs)在NSCs的维持、分化和成熟中起着至关重要的作用。本文主要综述了DUBs与NSCs的关系，并进一步总结了DUBs调控NSCs生物学行为的最新研究进展。

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Effects of deubiquitylases on the biological behaviors of neural stem cells

New neurons are generated throughout life in distinct regions of the mammalian brain due to the proliferation and differentiation of neural stem cells (NSCs). Ubiquitin, a post-translational modification of cellular proteins, is an important factor in regulating neurogenesis. Deubiquitination is a biochemical process that mediates the removal of ubiquitin moieties from ubiquitin-conjugated substrates. Recent studies have provided growing evidence that deubiquitylases (DUBs) which reverse ubiquitylation process play critical roles in NSCs maintenance, differentiation and maturation. This review mainly focused on the relationship of DUBs and NSCs, and further summarized recent advances in our understanding of DUBs on regulating NSCs biological behaviors.

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来源期刊

Developmental Neurobiology 生物-发育生物学

CiteScore

6.50

自引率

0.00%

发文量

审稿时长

4-8 weeks

期刊介绍： Developmental Neurobiology (previously the Journal of Neurobiology ) publishes original research articles on development, regeneration, repair and plasticity of the nervous system and on the ontogeny of behavior. High quality contributions in these areas are solicited, with an emphasis on experimental as opposed to purely descriptive work. The Journal also will consider manuscripts reporting novel approaches and techniques for the study of the development of the nervous system as well as occasional special issues on topics of significant current interest. We welcome suggestions on possible topics from our readers.