造血干细胞供者的急性肾小球肾炎。

Clinical Nephrology. Case Studies Pub Date : 2021-07-01 eCollection Date: 2021-01-01 DOI:10.5414/CNCS110538
Preeti Chandra, Saurabh Dahiya, Gabriela Sanchez-Petitto, Jawad Malik, Jonathan Bolanos, Abdolreza Haririan, Matthew Weir, Cinthia Drachenberg, Aaron Rapoport
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引用次数: 1

摘要

粒细胞集落刺激因子(G-CSF)的使用与副作用相关,包括急性肾小球肾炎(GN)的报道,几乎所有这些都与免疫复合物相关。先前有一个儿童的少免疫GN报告,但ANCA(抗中性粒细胞胞浆抗体)阴性。我们描述了第一例因使用G-CSF进行外周血干细胞(PBSC)捐赠而加重的anca阳性少免疫GN病例,该患者之前没有血管炎史。鉴于G-CSF在PBSC捐赠和中性粒细胞减少相关的各种情况下的使用,重要的是肾科医生和血液科医生都意识到与使用相关的肾脏风险。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Acute glomerulonephritis in a hematopoietic blood stem cell donor.

Acute glomerulonephritis in a hematopoietic blood stem cell donor.

Use of granulocyte colony-stimulating factor (G-CSF) has been associated with side effects including reports of acute glomerulonephritis (GN), almost all of which have been immune complex associated. There is one prior report of pauci-immune GN in a child, but was negative for ANCA (anti-neutrophilic cytoplasmic antibodies). We describe the first case of ANCA-positive pauci-immune GN exacerbated by the use of G-CSF for peripheral blood stem cell (PBSC) donation in a patient with no prior history of vasculitis. Given the use of G-CSF in PBSC donation and neutropenias associated with various conditions, it is important that both the nephrologist and the hematologist are aware of the renal risks associated with its use.

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