首发精神病和多期精神分裂症患者大脑皮质厚度和旋回的变化。

IF 0.8 4区医学 Q4 NEUROSCIENCES

Archives Italiennes De Biologie Pub Date : 2021-03-31 DOI:10.12871/00039829202111

A Del Casale, M C Rossi-Espagnet, A Napolitano, M Lucignani, L Bonanni, G D Kotzalidis, A Buscajoni, L Manelfi, V Perrone, I Gualtieri, R Brugnoli, E De Pisa, P Girardi, A Romano, S Ferracuti, A Bozzao, M Pompili

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引用次数: 5

摘要

精神障碍的皮质厚度(CT)和局部旋转指数(LGI)可能显示与临床病程相关的改变。本观察性研究旨在分析精神分裂症患者与健康对照组(hc)的这些变量。我们比较了18例首发精神病患者、21例多期精神分裂症患者和16例hcc患者的CT和LGI。假阳性病例的CT校正(家庭误差率)显示，与左颞叶和顶叶、右颞叶、顶叶、枕叶和海马皮质的hcc相比，多发作组的hcc发生率降低。与hcc患者相比，首次发病患者的左下额皮质和中额皮质以及右梭状回、扣带回、舌回和海马旁回的家庭矫正LGI增加。晚期精神病没有出现LGI升高，这表明特定的CT和LGI改变可能是疾病不同阶段的基础。

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Cerebral cortical thickness and gyrification changes in first-episode psychoses and multi-episode schizophrenia.

Cortical thickness (CT) and local gyrification index (LGI) in psychotic disorders may show modifications that relate to clinical course. This observational study aimed to analyse such variables in patients with schizophrenia, compared to healthy controls (HCs). We compared CT and LGI of 18 patients with first-episode psychosis with that of 21 with multi-episode schizophrenia and 16 HCs. CT corrected for false-positive cases (Family-Wise Error Rate) showed a reduction in the multi-episode group compared to HCs in left temporal and parietal, and right temporal, parietal, occipital, and hippocampal cortices. Family-wise corrected LGI was increased in the left inferior and middle frontal cortices, and in the right fusiform gyrus, cingulate, lingual, and parahippocampal gyri in first onset patients compared to HCs. Increased LGI was absent from later stages of psychosis, suggesting that specific CT and LGI alterations may underlie different stages of illness.

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来源期刊

Archives Italiennes De Biologie 医学-神经科学

CiteScore

2.10

自引率

30.00%

发文量

审稿时长

>12 weeks

期刊介绍： Archives Italiennes de Biologie - a Journal of Neuroscience- was founded in 1882 and represents one of the oldest neuroscience journals in the world. Archives publishes original contributions in all the fields of neuroscience, including neurophysiology, experimental neuroanatomy and electron microscopy, neurobiology, neurochemistry, molecular biology, genetics, functional brain imaging and behavioral science. Archives Italiennes de Biologie also publishes monographic special issues that collect papers on a specific topic of interest in neuroscience as well as the proceedings of important scientific events. Archives Italiennes de Biologie is published in 4 issues per year and is indexed in the major collections of biomedical journals, including Medline, PubMed, Current Contents, Excerpta Medica.